Document Detail


Influence of various treatments including povidone-iodine and healing stimulatory reagents in a rabbit ear wound model.
MedLine Citation:
PMID:  22776519     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Selecting an appropriate treatment for a given case of skin wound is crucial for inducing optimal healing. We used an animal model consisting of normal rabbit ears in order to assess the efficacy of treatments for skin wounds with/without a wet dressing, anti-microbial reagent, or topical wound-stimulatory reagents. The degree of healing in each group was evaluated and compared using four histological parameters: (i) degree of reepithelialisation, (ii) amount of granulation tissue formation and (iii) the number of capillary lumens and (iv) fibroblasts in the granulation tissue. Treatment using wet dressings presented an increase in capillary number compared to the open dry wound. Although the retention of PI in wound tissue after application significantly inhibited reepithelialisation (P < 0·05), rinsing povidone-iodine (PI) off with saline after application was comparable in effect to using only a wet dressing. The three topical reagents, namely, basic fibroblast growth factor, prostaglandin E1 and dibutyryl cyclic adenosine monophosphate, significantly improved reepithelialisation (P < 0·05). In conclusion, wounds should be kept hydrated by applying topical reagents. If there are any signs of bacterial infection, PI can be applied if rinsed later with saline in order to minimise its cytotoxic effects.
Authors:
Keitaro Arai; Masashi Yamazaki; Tatsuo Maeda; Takaaki Okura; Ryoji Tsuboi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-9
Journal Detail:
Title:  International wound journal     Volume:  -     ISSN:  1742-481X     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230907     Medline TA:  Int Wound J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. International Wound Journal © 2012 Blackwell Publishing Ltd and Medicalhelplines.com Inc.
Affiliation:
K Arai, MD, Department of Dermatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan M Yamazaki, MD, PhD, Department of Dermatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan T Maeda, BS, Department of Dermatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan T Okura, MD, Department of Dermatology, Self Defense Force Hanshin Hospital, 4-1-50 Kushiro, Kawanishi, Hyogo, Japan R Tsuboi, MD, PhD, Department of Dermatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan.
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