Document Detail


Influence of various fatty acids on tumour growth in total parenteral nutrition.
MedLine Citation:
PMID:  7835386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of parenteral nutrition in tumour patients is to offer an alternative nutritional support to the patient without accelerating the growth of the tumour. For this purpose we fed a total of 100 rats, divided into five groups of 20 animals each (10 with and 10 without tumours), for a total period of 15 days with various nutritional regimes. Group 1 received glucose, group 2 long-chain triglycerides, group 3 medium-chain triglycerides (MCT), group 4 omega-3 fatty acids, and group 5 an oral diet. On the 10th day the Yoshida sarcoma in its ascites form was implanted into the tumour-bearing rats. In animals receiving MCT or omega-3 fatty acids tumour growth was considerably smaller than in the other groups (group 1 vs. groups 3 and 4; p < 0.05). Unfavourable effects of the administration of these fatty acids on the general condition of the animals were not observed [muscle nitrogen content (mg/kg body weight): MCT = 82.3, omega-3 fatty acids = 65.25]. The impulse cytophotometric measurements did not demonstrate any influence on the pattern of cell division (p > 0.05). We think that modulation of the immune system by feeding with MCT or omega-3 fatty acids was responsible for the reduced tumour growth in relation to the other groups. The extrapolation of these results to the clinical situation, however, may not be possible.
Authors:
U Wolters; H W Keller; R Becker; P Stickeler; M Dahlmeyer; J M Müller
Related Documents :
2997286 - Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids...
11352806 - Regulation of apolipoprotein secretion by long-chain polyunsaturated fatty acids in new...
2834356 - Production of eicosapentaenoic acid by marine bacteria.
15925286 - Influence of preoperative administration of omega-3 fatty acid-enriched supplement on i...
4096536 - Application of computer taxonomic techniques to the study of cutaneous propionibacteria...
24374906 - Interaction of valproic acid and the antidepressant drugs doxepin and venlafaxine: anal...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  26     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  1994  
Date Detail:
Created Date:  1995-03-01     Completed Date:  1995-03-01     Revised Date:  2006-11-30    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  288-97     Citation Subset:  IM    
Affiliation:
Department of Surgery, Cologne University, FRG.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Fatty Acids / pharmacology*
Male
Nitrogen / metabolism
Parenteral Nutrition, Total*
Rats
Rats, Sprague-Dawley
Sarcoma, Yoshida / metabolism,  pathology*
Triglycerides / pharmacology
Weight Gain
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Triglycerides; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of atropine and truncal vagotomy on the exocrine pancreatic function in dogs stimulated with ...
Next Document:  Enlargement of the right ventricular outflow tract and the pulmonary artery with a new biodegradable...