| Influence of various fatty acids on tumour growth in total parenteral nutrition. | |
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MedLine Citation:
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PMID: 7835386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of parenteral nutrition in tumour patients is to offer an alternative nutritional support to the patient without accelerating the growth of the tumour. For this purpose we fed a total of 100 rats, divided into five groups of 20 animals each (10 with and 10 without tumours), for a total period of 15 days with various nutritional regimes. Group 1 received glucose, group 2 long-chain triglycerides, group 3 medium-chain triglycerides (MCT), group 4 omega-3 fatty acids, and group 5 an oral diet. On the 10th day the Yoshida sarcoma in its ascites form was implanted into the tumour-bearing rats. In animals receiving MCT or omega-3 fatty acids tumour growth was considerably smaller than in the other groups (group 1 vs. groups 3 and 4; p < 0.05). Unfavourable effects of the administration of these fatty acids on the general condition of the animals were not observed [muscle nitrogen content (mg/kg body weight): MCT = 82.3, omega-3 fatty acids = 65.25]. The impulse cytophotometric measurements did not demonstrate any influence on the pattern of cell division (p > 0.05). We think that modulation of the immune system by feeding with MCT or omega-3 fatty acids was responsible for the reduced tumour growth in relation to the other groups. The extrapolation of these results to the clinical situation, however, may not be possible. |
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Authors:
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U Wolters; H W Keller; R Becker; P Stickeler; M Dahlmeyer; J M Müller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 26 ISSN: 0014-312X ISO Abbreviation: Eur Surg Res Publication Date: 1994 |
Date Detail:
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Created Date: 1995-03-01 Completed Date: 1995-03-01 Revised Date: 2006-11-30 |
Medline Journal Info:
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Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 288-97 Citation Subset: IM |
Affiliation:
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Department of Surgery, Cologne University, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fatty Acids / pharmacology* Male Nitrogen / metabolism Parenteral Nutrition, Total* Rats Rats, Sprague-Dawley Sarcoma, Yoshida / metabolism, pathology* Triglycerides / pharmacology Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Triglycerides; 7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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