Document Detail

Influence of various conditioning regimens on the outcome of bone marrow transplantation for leukemia.
MedLine Citation:
PMID:  1818295     Owner:  NLM     Status:  MEDLINE    
Allogeneic bone marrow transplantation is widely used for the treatment of leukemias. Relapse is one of the main complications. Various types of conditioning have been used. Most teams use a combination of cyclophosphamide and different modalities of total body irradiation. In some regimens, high dose alkylating drugs like Busulfan are substituted for radiation. None of these regimens has modified significantly the long term disease free survival, indicating the need for prospective randomized trials.
A Devergie; G Socie; H Esperou-Bourdeau; P Ribaud; R Traineau; E Gluckman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nouvelle revue française d'hématologie     Volume:  33     ISSN:  -     ISO Abbreviation:  Nouv Rev Fr Hematol     Publication Date:  1991  
Date Detail:
Created Date:  1992-07-15     Completed Date:  1992-07-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7909092     Medline TA:  Nouv Rev Fr Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  437-9     Citation Subset:  IM    
Service de Greffe de Moelle, Hôpital Saint-Louis, Paris, France.
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MeSH Terms
Antineoplastic Agents / administration & dosage
Bone Marrow Transplantation*
Busulfan / administration & dosage
Combined Modality Therapy
Cyclophosphamide / administration & dosage
Leukemia / therapy*
Whole-Body Irradiation
Reg. No./Substance:
0/Antineoplastic Agents; 50-18-0/Cyclophosphamide; 55-98-1/Busulfan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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