Document Detail

Influence of vagotomy upon GIP release in patients with peptic ulcer.
MedLine Citation:
PMID:  6385345     Owner:  NLM     Status:  MEDLINE    
Twenty-two vagotomized peptic ulcer patients were studied on the influence of vagotomy on the release of GIP. Moreover, the relationship between acid output and GIP release was analyzed. These patients underwent one of the three types of operation; truncal vagotomy with pyloroplasty (TV + P) selective vagotomy with pyloroplasty (SV + P) and selective vagotomy with antrectomy (SV + A). Before and after surgery, a gastric juice study and an oral glucose tolerance test were performed on separate days. Maximum acid output in response to tetragastrin correlated significantly with integrated GIP response after oral glucose loading. In the SV + P group, the response of GIP was slightly greater after surgery. In the SV + A group, the integrated GIP response diminished postoperatively, although, after surgery, GIP reached its peak sooner. The integrated GIP response was greater in the SV + P group than in the TV + P group. The response of GIP was less in the SV + A group than in the SV + P group. These changes were insignificant. In conclusion, it is presumed that GIP release is affected by gastric acid, gastric emptying time, intestinal transit time and vagal nerve action.
M Imamura; J Kameyama; H Naito; T Sato; A Ohneda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  143     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-11-20     Completed Date:  1984-11-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  335-44     Citation Subset:  IM    
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MeSH Terms
Blood Glucose / analysis
Gastric Acid / secretion
Gastric Inhibitory Polypeptide / blood*
Gastrointestinal Hormones / blood*
Glucose / diagnostic use
Insulin / blood
Middle Aged
Peptic Ulcer / metabolism,  surgery*
Tetragastrin / diagnostic use
Vagotomy, Proximal Gastric
Reg. No./Substance:
0/Blood Glucose; 0/Gastrointestinal Hormones; 11061-68-0/Insulin; 1947-37-1/Tetragastrin; 50-99-7/Glucose; 59392-49-3/Gastric Inhibitory Polypeptide

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