Document Detail

Influence of upper airway negative pressure reflex on response to airway occlusion in sleeping infants.
MedLine Citation:
PMID:  2793677     Owner:  NLM     Status:  MEDLINE    
Artificially produced upper airway suction inhibits the diaphragm in animals and infants; however, the effects of spontaneously generated suction in humans are unknown. We studied nine tracheostomized infants because separation of the upper from the lower airway allowed us to channel suction created by an occluded inspiratory effort to both upper and lower airways (upper + lower airway occlusions) or to the lower airway only (lower airway occlusion). The tracheostomy airway was briefly occluded at end expiration during quiet sleep. In upper + lower airway occlusions, peak airway pressure of the first occluded breath was less negative and rate of pressure decrease slower than that of lower airway occlusions, indicating that upper airway suction inhibits thoracic inspiratory muscles. The threshold for this response was less than or equal to 4 cmH2O suction pressure. The effect on inspiratory time was variable. A decrease in slope of the inspiratory pressure waveform occurring at approximately 0.12 s after inspiration onset was more marked in upper + lower airway occlusions. We conclude that infants have an upper airway reflex response to inspiratory pressure that alters not only the peak and slope but also the shape of the inspiratory pressure waveform.
B T Thach; G L Schefft; D L Pickens; A P Menon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  67     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-11-15     Completed Date:  1989-11-15     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  749-55     Citation Subset:  IM    
Edward Mallinckrodt Department of Pediatrics, Children's Hospital, Washington University School of Medicine, St. Louis, Missouri.
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MeSH Terms
Airway Obstruction / complications*
Infant, Newborn
Muscles / physiology
Pulmonary Ventilation
Respiratory System / physiopathology*
Tidal Volume
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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