| Influence of trifluoperazine and verapamil on the isolated perfused rat kidney. | |
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MedLine Citation:
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PMID: 8842699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Isolated rat filtering kidneys were perfused with Ringer bicarbonate solutions containing either trifluoperazine (TFP, 50 microM) or verapamil (VER, 100 microM) to prevent tissue dysfunctions observed during perfusion. 2. Water, sodium and chloride kidney contents diminished under both treatments as compared with control preparations, and potassium content increased. 3. When albumin concentration was increased (10 g%) in the perfusion medium (nonfiltering kidney preparation) these effects of TFP or VER were not observed. 4. Lipid peroxidation and LDH release diminished significantly under 50 microM TFP but only slightly under 100 microM VER. |
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Authors:
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S Weinschelbaum-Jairala; J E Ochoa; M M Elías |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: General pharmacology Volume: 27 ISSN: 0306-3623 ISO Abbreviation: Gen. Pharmacol. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1997-01-30 Completed Date: 1997-01-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7602417 Medline TA: Gen Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 911-5 Citation Subset: IM |
Affiliation:
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Instituto de Fisiología Experimental, CONICET, Rosario, Argentina. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antipsychotic Agents / pharmacology* Biological Markers Calcium Channel Blockers / pharmacology* Kidney / cytology, drug effects, metabolism* Kidney Cortex / drug effects, enzymology, metabolism Kidney Diseases / metabolism, pathology L-Lactate Dehydrogenase / metabolism Lipid Peroxidation / drug effects* Male Perfusion Rats Rats, Wistar Trifluoperazine / pharmacology* Verapamil / pharmacology* Water-Electrolyte Balance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Biological Markers; 0/Calcium Channel Blockers; 117-89-5/Trifluoperazine; 52-53-9/Verapamil; EC 1.1.1.27/L-Lactate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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