| Influence of treatment delay on long-term left ventricular function in patients with acute myocardial infarction successfully treated with primary angioplasty. | |
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MedLine Citation:
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PMID: 11275927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Myocardial salvage has been shown to be dependent on the time elapsed from the onset of acute myocardial infarction (AMI) to reperfusion. The aim of this study was to evaluate the importance of time to reperfusion for left ventricular function recovery after primary angioplasty (percutaneous transluminal coronary angioplasty [PTCA]) for AMI. METHODS: Ninety-five patients undergoing long-term successful PTCA for AMI were studied. Echocardiography was performed before and 3, 7, 30, 90, and 180 days after PTCA. End-diastolic volume index (EDVI) and end-systolic volume index (ESVI), ejection fraction, and left ventricular wall motion score index (WMSI) were evaluated. RESULTS: Patients were divided into group A, 23 patients reperfused within 2 hours; group B, 32 patients reperfused between 2 and 4 hours; group C, 22 patients reperfused between 4 and 6 hours; and group D, 18 patients reperfused between 6 and 12 hours. Both EDVI and ESVI were reduced in groups A and B at 90 days. Groups C and D did not show any changes of EDVI and ESVI at any stage throughout the study. Ejection fraction improved only in groups A and B at 30, 90, and 180 days. At study entry, WMSI was similar in all groups. After 7 days, in group A and in group B, WMSI was improved, no changes were observed in group C, and a mild deterioration was observed in group D at 3 and 7 days. Subsequent evaluations showed progressive improvement of WMSI in all groups. CONCLUSIONS: Myocardial salvage is achieved only in patients revascularized within 4 hours from AMI onset. However, revascularization after 6 hours may be worthwhile by preventing ventricular remodeling. |
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Authors:
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I Sheiban; G Fragasso; C Lu; S Tonni; G P Trevi; S L Chierchia |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 141 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-03-29 Completed Date: 2001-05-17 Revised Date: 2006-02-27 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 603-9 Citation Subset: AIM; IM |
Affiliation:
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Divisione di Cardiologia Universitaria, Dipartimento di Medicina Interna, Università di Torino, Ospedale San Giovanni Batista, Corso Bramante 88/90-10126 Torino, Italy. isheiban@yahoo.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angioplasty, Transluminal, Percutaneous Coronary* Coronary Angiography Female Humans Male Middle Aged Myocardial Infarction / physiopathology*, radiography, therapy* Prognosis Time Factors Ventricular Function, Left* |
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