Document Detail

Influence of treated blood pressure on progression of silent cerebral infarction.
MedLine Citation:
PMID:  10403612     Owner:  NLM     Status:  MEDLINE    
PURPOSE AND METHODS: To examine whether treatment for hypertensive patients prevents the progression of cerebral infarction, we performed magnetic resonance imaging (MRI) repeatedly at mean intervals of 22 months on 117 Japanese subjects aged 65-89 (mean 74 years), including 84 hypertensive patients. The patients were given various anti-hypertensive agents, and the blood pressure of each patient was monitored periodically during the observation period. Depending on the average blood pressure at the end of the follow-up period, hypertensive patients were classified into three subgroups: normotension (N), borderline (B) and hypertension (H). None had a prior history of symptomatic cerebral infarction and neurological abnormalities. The number of infarcted lesions were determined on brain MRI by two independent observers. RESULTS: Silent cerebral infarction (SCI) lesions were observed in 42 hypertensive subjects (50.0%) and in eight control subjects (24.2%) on enrollment. The numbers of SCI lesions increased in 33 hypertensive subjects (39.3%) and three control subjects (9.1%) during the observation period. In the hypertensive subjects, an increased number of infarcted lesions was found in six of 28 subjects in group N (21.4%), 17 of 44 in group B (38.6%), and 10 of 12 in group H (83.3%). Thus, blood pressure controlled to the normal level appears to result in a lower incidence of progression of infarcted areas in patients with hypertension (N versus H, P < 0.001). CONCLUSION: Our data indicate that an appropriate anti-hypertensive treatment reduces the risk of a cerebrovascular accident in hypertensive patients.
T Sugiyama; J D Lee; H Shimizu; S Abe; T Ueda
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  17     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-10-19     Completed Date:  1999-10-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  679-84     Citation Subset:  IM    
The First Department of Internal Medicine, Fukui Medical University, Japan.
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MeSH Terms
Aged, 80 and over
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects
Cerebral Infarction / diagnosis,  etiology,  prevention & control*
Disease Progression
Hypertension / complications,  drug therapy*
Magnetic Resonance Imaging
Prospective Studies
Risk Factors
Reg. No./Substance:
0/Antihypertensive Agents

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