Document Detail


Influence of transmyocardial laser revascularization (TMLR) on regional cardiac function and metabolism in an isolated hemoperfused working pig heart.
MedLine Citation:
PMID:  12487395     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanism of an indirect revascularization in ischemic myocardium by transmyocardial laser revascularization (TMLR) is not yet fully understood. An improvement of clinical symptoms caused by TMLR is reported in many clinical trials with patients in which a direct revascularization is not possible. An increase of myocardial perfusion through laser channels is doubtful, because the myocardial pressure in the wall is higher than in the cavum. Therefore we measured the local cardiac function (intramyocardial pressure, wall thickness, pressure-length curves) and acute metabolic changes (tissue lactate content, tissue pO2) in ischemic and nonischemic regions before and after TMLR in isolated hemoperfused pig hearts. An isolated heart was chosen because it enabled us to separate coronary flow from flow through ventricular channels. The ischemia was induced by coronary occlusion or microembolization (eight hearts each). It should be noted that microembolization leads to conditions which are more comparable with those found in patients selected for TMLR. In the isolated working heart, the coronary perfusion can be controlled independently from perfusion through the ventricular cavum. Under the ischemic conditions mentioned above, we observed that the intramyocardial pressure in the ischemic region decreased below the left ventricular pressure, so one premise for indirect perfusion was met. TMLR after microembolization led to a significant improvement of regional cardiac work and the tissue oxygen pressure. These acute effects demonstrate the possibility of functional and metabolic amelioration by TMLR after ischemia induced by microembolization in an isolated hemoperfused pig heart.
Authors:
D Modersohn; S Eddicks; I Ast; S Holinski; W Konertz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  25     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-12-18     Completed Date:  2003-03-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  1074-81     Citation Subset:  IM    
Affiliation:
Clinic for Cardiovascular Surgery, Charité, Humboldt-University, Berlin, Germany. Diethelm.Modersohn@charite.de
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Disease Models, Animal
Female
Heart Arrest, Induced
Heart Function Tests
Hemodynamics / physiology
Laser Therapy / methods*
Myocardial Contraction / physiology
Myocardial Ischemia / metabolism*,  surgery*
Myocardial Revascularization / instrumentation,  methods*
Probability
Random Allocation
Reference Values
Sensitivity and Specificity
Statistics, Nonparametric
Swine
Ventricular Function, Left / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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