Document Detail

Influence of transient overdistension on bladder wall morphology and enzyme histochemistry.
MedLine Citation:
PMID:  9458507     Owner:  NLM     Status:  MEDLINE    
Bladder overdistension has been found to cause transitional morphological changes in innervation which correlate with changes in micturition and bladder contractility. We investigated the influence of overdistension on bladder wall morphology using histological and enzyme histochemical methods. Overdistension was induced in female rats for 3 h by forced diuresis and balloon obstruction of the bladder neck. Oedema was seen beneath the mucosa at 12 h, with hyperemia and haemorrhages. The urothelium was mostly intact, although enzymes leaked out of the epithelial cells. The changes were increased at 24 h. The urothelium also showed some disruptions and degenerative vacuolization. The oedema reached its maximum at 48 h, and large numbers of inflammatory cells were also seen. The urothelium was disruptured in many places and vacuolated, but the subendothelial capillaries remained normal. Damage to some muscle cells was seen. After 7 days the oedema had disappeared and the urothelium was continuous. Enlarged nuclei were seen as white spots in the epithelial cells. Numbers of inflammatory cells were similar to those in the controls. Overdistension causes damage primarily to the bladder urothelium, and to a lesser extent to the muscular layer. Urothelium integrity is destroyed for several days, which makes it possible for various substances to penetrate the bladder wall and allows for bacterial adherence. The damage however is, almost completely healed within one week.
M Leppilahti; J Hirvonen; T L Tammela
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of urology and nephrology     Volume:  31     ISSN:  0036-5599     ISO Abbreviation:  Scand. J. Urol. Nephrol.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-03-20     Completed Date:  1998-03-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0114501     Medline TA:  Scand J Urol Nephrol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  517-22     Citation Subset:  IM    
Division of Urology, University of Oula, Finland.
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MeSH Terms
Alkaline Phosphatase / metabolism*
Bacterial Adhesion
Dilatation, Pathologic / pathology
Edema / pathology
Epithelial Cells / enzymology
L-Lactate Dehydrogenase / metabolism*
Rats, Sprague-Dawley
Urinary Bladder / enzymology,  pathology*
Reg. No./Substance:
EC Dehydrogenase; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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