Document Detail

Influence of tramadol on the ventilatory response to hypoxia in humans.
MedLine Citation:
PMID:  10992826     Owner:  NLM     Status:  MEDLINE    
We studied the effect of tramadol on the ventilatory response to 7 min acute isocapnic hypoxia (SpO2 85.1 (SD 0.4)%) during steady mild hypercapnia (PE'CO2 0.7 kPa above normoxic baseline) in 14 healthy volunteers (seven male). The acute hypoxic response was measured before and 1 h after oral placebo or tramadol (100 mg). After tramadol, ventilation during mild hypercapnia (mean 11.28 litres min-1) was significantly less (P < 0.05) than during placebo baseline (13.93 litres min-1), tramadol baseline (14.63 litres min-1), or after placebo (14.95 litres min-1), confirming that tramadol has a small depressive effect on the hypercapnic ventilatory response. There was no significant difference in the hypoxic ventilation/SpO2 response (1 min-1 %-1) measured during the placebo baseline (0.99), placebo (1.18), tramadol baseline (0.78) or tramadol (0.68) runs. These data suggest that tramadol does not depress the hypoxic ventilatory response.
P M Warren; J H Taylor; K E Nicholson; P K Wraith; G B Drummond
Related Documents :
12706066 - Intermittent hypoxia and plasticity of respiratory chemoreflexes in metamorphic bullfro...
15059786 - Ventilatory responses to inhaled carbon dioxide, hypoxia, and exercise in idiopathic hy...
3003346 - Role of 5'-nucleotidase in adenosine-mediated renal vasoconstriction during hypoxia.
3559986 - Differential effects of hypoxia on the turnover of norepinephrine and epinephrine in th...
12728976 - Dose-response relationships of propranolol in chinese subjects with different cyp2d6 ge...
22200656 - Neuroelectric indices of goal maintenance following a single bout of physical activity.
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  85     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-21     Completed Date:  2000-09-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  211-6     Citation Subset:  IM; S    
Department of Medical and Radiological Science, University of Edinburgh, Royal Infirmary, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analgesics, Opioid / therapeutic use*
Anoxia / drug therapy*
Cross-Over Studies
Hypercapnia / drug therapy*
Respiration / drug effects*
Tramadol / therapeutic use*
Reg. No./Substance:
0/Analgesics, Opioid; 27203-92-5/Tramadol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Enoximone pharmacokinetics in infants.
Next Document:  Use of intravenous patient-controlled analgesia for the documentation of synergy between tramadol an...