| Influence of timing and magnitude of arterial wave reflection on left ventricular relaxation. | |
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MedLine Citation:
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PMID: 11247800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of timing and magnitude of arterial wave reflection (WR) on afterload-dependent relaxation was evaluated in patients with a variety of heart diseases (group 1, age < 30 yr; group 2, age > 40 yr) and in dogs. While both femoral arteries were compressed (FC), WR returned just after the dicrotic notch (early diastole) in group 1 but before the dicrotic notch (late systole) in group 2. The time constant of the left ventricular pressure decay (tau) was shortened during FC in group 1, whereas it was prolonged in group 2. In dogs, a constriction of the thoracic aorta induced a late systolic augmentation of WR with a prolongation of tau (cf. group 2), whereas constriction of the lower abdominal aorta induced an early diastolic augmentation of WR with a shortening of tau (cf. group 1). With aortic constriction, coronary flow increased, and there was a close correlation between the peak change in backward aortic pressure and that in coronary flow regardless of the timing of WR. Thus the time at which WR returns during the cardiac cycle may have an important effect on left ventricular relaxation and coronary flow. |
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Authors:
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M Yano; M Kohno; S Kobayashi; M Obayashi; K Seki; T Ohkusa; T Miura; T Fujii; M Matsuzaki |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 280 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-03-15 Completed Date: 2001-04-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1846-52 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan. yanoma@po.cc.yamaguchi-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Animals Aorta, Abdominal / physiology Aorta, Thoracic / physiology Blood Pressure Coronary Circulation / physiology Coronary Disease / physiopathology* Dogs Femoral Artery / physiology, physiopathology* Heart Diseases / physiopathology* Heart Rate Hemodynamics / physiology* Humans Middle Aged Pulse Regression Analysis Vasoconstriction Ventricular Function, Left / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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