Document Detail

Influence of time at which oxytocin is administered during labor on uterine activity and perinatal death in pigs.
MedLine Citation:
PMID:  17657355     Owner:  NLM     Status:  MEDLINE    
Oxytocin is extensively used to induce or augment uterine contractions, especially to facilitate the third stage of labor in humans. Administration of oxytocin to parturient sows reduces duration of labor whereas mortality of the offspring may remain unchanged. This study aimed to evaluate whether time of administration of oxytocin during parturition may alter the uterine response and fetal outcomes. Two hundred parturient sows were randomly assigned to intramuscularly receive either saline solution (control group) or oxytocin 0.083 IU/kg immediately after the delivery of the 1st, 4th or 8th piglet (groups O-1, 0-4 and 0-8, respectively). Uterine effects and fetal outcomes were registered in all groups. The duration of labor was 20-40 min shorter (P < 0.0001) and time interval between babies was reduced by 3-5 min (P < 0.0001) in the three groups receiving oxytocin. The duration and intensity of contractions, meconium-stained piglets and intrapartum deaths decreased as time at which oxytocin administered during labor was increased. In group 0-8, we observed approximately 70% less meconium-stained piglets and intrapartum deaths than in the control group. In conclusion, oxytocin administered at early phases of parturition to sows may increase duration and intensity of uterine contractions as well as adverse fetal outcomes.
Daniel Mota-Rojas; Dina Villanueva-García; Elvia Y Velazquez-Armenta; Alejandro A Nava-Ocampo; Ramiro Ramírez-Necoechea; María Alonso-Spilsbury; María E Trujillo
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-07-19
Journal Detail:
Title:  Biological research     Volume:  40     ISSN:  0716-9760     ISO Abbreviation:  Biol. Res.     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-27     Completed Date:  2008-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9308271     Medline TA:  Biol Res     Country:  Chile    
Other Details:
Languages:  eng     Pagination:  55-63     Citation Subset:  IM    
Research Area: Ecodesarrollo de la Producción Animal, Department of Animal Production & Agriculture, Universidad Autónoma Metropolitana-Xochimilco, México DF, Mexico.
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MeSH Terms
Animals, Newborn
Dose-Response Relationship, Drug
Myometrium / drug effects*,  physiology
Oxytocics / administration & dosage*,  adverse effects
Oxytocin / administration & dosage*,  adverse effects
Parturition / drug effects*,  physiology
Stillbirth / veterinary*
Time Factors
Uterine Contraction / drug effects*,  physiology
Reg. No./Substance:
0/Oxytocics; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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