| Influence of thyroid dysfunction on liver lipid peroxidation and antioxidant status in experimental rats. | |
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MedLine Citation:
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PMID: 19540741 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to evaluate the effects of dysthyroidism on lipid peroxidation, antioxidants status, liver, and serum dysfunction parameters in the hypo-/hyperthyroidism-induced rats. Hypothyroidism and hyperthyroidism conditions were induced for 5 weeks by administration of 0.05% benzythiouracile (BTU) and l-thyroxine sodium salt (0.0012%), in drinking water, respectively. The enzymatic activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and the lipid peroxidation product; thiobarbituric acid reacting substances (TBARS) were measured in liver as indicators of oxidative damage. However, liver dysfunction parameters represented by the activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and gamma glutamyl transferase (GGT), were measured in serum. In hyperthyroidism rats, the TBARS contents of liver have significantly increased compared to those in hypothyroid rats and the controls (p<0.001), associated with a fall of the total antioxidant status (TAS) in the serum of the hyperthyroid rats. The SOD, CAT, and GPx activities in liver of hyperthyroid rats have significantly increased compared to hypothyroid rats and the controls (p<0.001). The AST, ALT, LDH, GGT, and ALP activities increased in the hyperthyroidism rats (p<0.05). We conclude that thyroid dysfunction induces oxidative stress and modifies some biochemical parameters of liver. Our results show the occurrence of a state of oxidizing stress in relation to hyperthyroidism. |
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Authors:
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Mahfoud Messarah; Amel Boumendjel; Amel Chouabia; Fahima Klibet; Cherif Abdennour; Mohamed Salah Boulakoud; Abdelfattah El Feki |
Publication Detail:
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Type: Journal Article Date: 2009-06-21 |
Journal Detail:
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Title: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Volume: 62 ISSN: 1618-1433 ISO Abbreviation: Exp. Toxicol. Pathol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-17 Completed Date: 2010-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208920 Medline TA: Exp Toxicol Pathol Country: Germany |
Other Details:
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Languages: eng Pagination: 301-10 Citation Subset: IM |
Affiliation:
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Animal Ecophysiology Laboratory, Department of Biology, Science Faculty, Badji Mokhtar University, BP 12 Sidi Amar, 23000 Annaba, Algeria. mmessarahdz@yahoo.fr <mmessarahdz@yahoo.fr> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / metabolism Catalase / metabolism Glutathione Peroxidase / metabolism Hyperthyroidism / complications, metabolism* Hypothyroidism / complications, metabolism* Lipid Peroxidation / physiology* Liver Diseases / etiology, metabolism* Male Oxidative Stress / physiology* Rats Rats, Wistar Superoxide Dismutase / metabolism Thiobarbituric Acid Reactive Substances / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Thiobarbituric Acid Reactive Substances; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
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