Document Detail

Influence of therapy on silent ischemia and ventricular arrhythmias in hypertensive patients.
MedLine Citation:
PMID:  1723447     Owner:  NLM     Status:  MEDLINE    
To assess whether therapy with hydrochlorothiazide (HCTZ) or the calcium antagonist nitrendipine influences silent ischemia or arrhythmias, we studied 10 asymptomatic hypertensive male patients with positive Tl-201 scintigraphy in a double-blind, crossover protocol. Blood pressure (BP) and 48-h Holter monitoring were obtained after 2 weeks of placebo and 8 weeks each of HCTZ and nitrendipine therapy. Ischemia was defined as greater than 1 mm ST-segment depression lasting greater than 1 min and was quantified by the number of episodes, duration, and area under the curve (AUC). The mean number of PVCs per hour and the number of episodes of ventricular tachycardia (greater than 3 beats) were also assessed. Diastolic BP was significantly reduced by both HCTZ and nitrendipine (98 +/- 6 vs. 90 +/- 6 vs. 88 +/- 7 mm Hg, respectively, p less than 0.05), but systolic BP was unchanged for either drug. The number of ischemic episodes was reduced by nitrendipine, from 2.4 +/- 3 to 0.8 +/- 2, (p less than 0.05) but not by HCTZ (2.4 +/- 3 to 1.5 +/- 3, p = NS). The duration of ischemia (37 +/- 43 vs. 5 +/- 9 min, p less than 0.05) as well as the AUC (41 +/- 45 vs. 7 +/- 14 mm/min, p less than 0.05) were reduced only by nitrendipine. The number of PVCs rose with HCTZ therapy, from 19 +/- 34 to 69 +/- 88 (p less than 0.05) and was unchanged by nitrendipine (19 +/- 34 vs. 19 +/- 40, p = NS).(ABSTRACT TRUNCATED AT 250 WORDS)
J Szlachcic; J F Tubau; B O'Kelly; S Ammon; B M Massie
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  18 Suppl 1     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-10     Completed Date:  1992-03-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S106-8     Citation Subset:  IM    
Department of Cardiology, Veterans Administration Medical Center, San Francisco, California.
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MeSH Terms
Arrhythmias, Cardiac / drug therapy*,  etiology,  physiopathology
Blood Pressure / drug effects,  physiology
Coronary Disease / drug therapy*,  etiology
Electrocardiography, Ambulatory
Heart Ventricles / drug effects
Hydrochlorothiazide / therapeutic use
Hypertension / complications,  drug therapy*,  physiopathology
Middle Aged
Nitrendipine / therapeutic use
Ventricular Function
Reg. No./Substance:
39562-70-4/Nitrendipine; 58-93-5/Hydrochlorothiazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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