| Influence of testosterone on ventilation and chemosensitivity in male subjects. | |
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MedLine Citation:
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PMID: 4066575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is increasing evidence that men have higher ventilatory responses to chemical stimuli than age-matched women and that certain disorders of respiratory rhythmicity, particularly sleep apnea, occur more commonly in men. Accordingly, we studied the influence of the male hormone, testosterone, on the control of breathing. Twelve hypogonadal males were studied at least 30 (mean +/- SE: 69.7 +/- 8.9) days after discontinuing testosterone replacement and again following hormone administration. In each subject plasma testosterone concentration, metabolic rate [O2 consumption (VO2) and CO2 production (VCO2)], minute ventilation (VE), and chemosensitivity [hypoxic (HVR) and hypercapnic (HCVR) ventilatory responses] were determined on and off hormone replacement. With testosterone administration VO2 increased from 248 +/- 15 to 276 +/- 18 ml/min (P less than 0.05), with VCO2 showing a similar but nonsignificant trend. This was associated with an increase in VE from 8.41 +/- 0.78 to 9.91 +/- 0.75 l/min (P less than 0.05) but no change in PCO2. The HVR, expressed as A, increased 44% with hormone replacement from a value of 122 +/- 23 to 176 +/- 28 (P less than 0.01), whereas the HCVR was minimally affected by testosterone administration. These findings may in part explain the previously described differences between male and female subjects in hypoxic sensitivity. |
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Authors:
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D P White; B K Schneider; R J Santen; M McDermott; C K Pickett; C W Zwillich; J V Weil |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 59 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1985 Nov |
Date Detail:
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Created Date: 1986-01-06 Completed Date: 1986-01-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1452-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Humans Hypogonadism / physiopathology* Male Middle Aged Oxygen Consumption / drug effects Pulmonary Gas Exchange / drug effects Respiration / drug effects* Testosterone / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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AG-04491/AG/NIA NIH HHS; HL-01316/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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