Document Detail

Influence of temporal smoothing on quantitation of left ventricular function by gated blood pool scintigraphy.
MedLine Citation:
PMID:  2529757     Owner:  NLM     Status:  MEDLINE    
Frequently, indexes of systolic and diastolic left ventricular (LV) function obtained from radionuclide angiography are computed after the LV time-activity curve has been temporally smoothed. This smoothing process may introduce important systematic errors into the analysis. To assess this potential effect, high temporal resolution time-activity curves (20 ms/point) were obtained in 113 normal subjects, 175 patients with coronary artery disease and 171 patients with hypertrophic cardiomyopathy. The curves were then subjected to 0-, 3-, 5-, 7- and 9-point temporal smoothing. In each group, increased smoothing progressively and consistently underestimated ejection fraction by up to 5% (p less than 0.001) and peak ejection rate by up to 14% (p less than 0.001). A greater effect on peak filling rate was observed: 5-point and 9-point smoothing reduced peak filling rate by 10% and 23% in normal subjects, 3% and 10% in patients with coronary artery disease and 7% and 15%, respectively, in patients with hypertrophic cardiomyopathy (all p less than 0.001). These errors were compounded further when the same data obtained at lower temporal resolution (40 ms/point) were analyzed: 5-point and 9-point smoothing resulted in underestimation of peak filling rate by 20% and 46% in normal subjects, 13% and 43% in coronary artery disease and 16% and 34% in hypertrophic cardiomyopathy. The underestimation was not uniform, and its magnitude varied considerably among individuals in each of the 3 groups. Thus, smoothing of LV time-activity curves may result in significant systematic errors in computation of indexes of LV systolic and diastolic function, especially in data with poor temporal resolution. These concepts apply to other imaging methods, such as magnetic resonance imaging and cine-computed tomography, that assess LV function from the LV volume curve. Although ejection fraction is affected only mildly by these errors, both peak filling rate and peak ejection rate may be severely underestimated.
R O Bonow; S L Bacharach; C Crawford-Green; M V Green
Related Documents :
20329487 - Functional anatomy of normal mitral valve-left ventricular complex by real-time, three-...
25117587 - Post-operative echocardiographic evaluation of bioprosthetic mitral valve implantation ...
16618817 - Myocardial structure and function differ in systolic and diastolic heart failure.
15734427 - Facilitated minimally invasive left ventricular epicardial lead placement.
24979117 - Acute coronary syndromes in patients with multivessel disease: the key role of optical ...
8047317 - Decreased 123i-mibg uptake and increased clearance in various cardiac diseases.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  64     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-09     Completed Date:  1989-11-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  921-5     Citation Subset:  AIM; IM    
Cardiology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiomegaly / radionuclide imaging*
Coronary Disease / radionuclide imaging*
Gated Blood-Pool Imaging*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Importance of overweight in studies of left ventricular hypertrophy and diastolic function in mild s...
Next Document:  Evaluation of menogaril in patients with metastatic sarcomas and no prior chemotherapy exposure.