| Influence of temperature on basal and induced hepatic monooxygenase activity in rats of different ages. | |
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MedLine Citation:
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PMID: 3878705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of temperature on the rates of ethylmorphine N-demethylation and ethoxycoumarin O-deethylation was studied with liver homogenates prepared from 1- to 120-day-old rats. Breaks at temperatures of 21.5-28.0 degrees C were observed in the Arrhenius plots of these reactions, differences being dependent mainly on age of the animals rather than on reaction type. No breaks could be demonstrated for ethylmorphine N-demethylation with liver homogenates of 10- and 120-day-old rats and for ethoxycoumarin O-deethylation in newborn and 120-day-old rats. In poikilothermic 3-, 10- and homothermic 30-day-old rats ethylmorphine N-demethylation rate was dependent on incubation temperature (7, 20 and 37 degrees C). The relative increase in N-demethylation rate after phenobarbital treatment was most marked in 30-day-old rats at an incubation temperature of 37 degrees C. In infantile rats the relative induction was highest at 7 degrees C. |
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Authors:
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W Klinger; D Müller |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Biomedica biochimica acta Volume: 44 ISSN: 0232-766X ISO Abbreviation: Biomed. Biochim. Acta Publication Date: 1985 |
Date Detail:
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Created Date: 1986-01-31 Completed Date: 1986-01-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8304435 Medline TA: Biomed Biochim Acta Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 1181-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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7-Alkoxycoumarin O-Dealkylase Age Factors Animals Benzoflavones / pharmacology Ethylmorphine-N-Demethylase / metabolism* Female Liver / drug effects, enzymology* Male Oxidoreductases, N-Demethylating / metabolism* Oxygenases / metabolism* Phenobarbital / pharmacology Rats Rats, Inbred Strains Temperature Thermodynamics beta-Naphthoflavone |
| Chemical | |
Reg. No./Substance:
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0/Benzoflavones; 50-06-6/Phenobarbital; 6051-87-2/beta-Naphthoflavone; EC 1.13.-/Oxygenases; EC 1.14.13.-/7-Alkoxycoumarin O-Dealkylase; EC 1.5.-/Oxidoreductases, N-Demethylating; EC 1.5.3.-/Ethylmorphine-N-Demethylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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