| Influence of temperature on activity of the isolated whole bladder preparation of neonatal and adult rats. | |
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MedLine Citation:
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PMID: 10644645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The temperature sensitivity of in vitro whole bladder preparations from neonatal and adult rats with or without chronic partial urethral obstruction was investigated. After the bladder was filled to a volume eliciting isovolumetric contractions, temperature was changed between 19 and 38 degrees C. In all preparations, higher temperatures were associated with higher frequencies of spontaneous intravesical pressure waves (IVPW). In 1- to 2-wk-old neonates, IVPW amplitude increased as the temperature increased; however, in older neonates and normal adults, the opposite occurred. The transition period was at 3 wk of age when bladder volume also markedly increased. At this age as well as in adult rats with outlet obstruction, changing temperature had little influence on the amplitude of IVPW. Thus obstructed outlet bladders and 3-wk-old bladders had similar properties. It is concluded that the properties of bladder muscle are changed during postnatal maturation and that in 3-wk-old rats, when brain control of voiding is emerging, micturition is abnormal, leading to obstructive changes in bladder muscle. |
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Authors:
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K Sugaya; W C de Groat |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 278 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-06-21 Completed Date: 2000-06-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R238-46 Citation Subset: IM |
Affiliation:
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Department of Urology, Faculty of Medicine, University of the Ryukyus, Okinawa, 903-0215, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Animals, Newborn / growth & development, physiology* Behavior, Animal / physiology Electric Stimulation Female Male Muscle Contraction / physiology Muscle, Smooth / physiology Pressure Rats Rats, Sprague-Dawley Reference Values Sympathectomy Temperature* Urinary Bladder / innervation, physiology* Urinary Bladder Neck Obstruction / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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DK-49430/DK/NIDDK NIH HHS; DK-51402/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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