Document Detail

Influence of sympathetic tone on ventricular fibrillation threshold during experimental coronary occlusion.
MedLine Citation:
PMID:  1146697     Owner:  NLM     Status:  MEDLINE    
The effects of increased and decreased cardiac sympathetic tone and coronary occlusion on ventricular fibrillation were determined in 14 open chest dogs anesthetized with sodium pentobarbital. Heart rate was kept constant by pacing the right atrium at cycle lengths of 500 msec. Ventricular fibrillation threshold was measured by delivering 350 msec trains of constant current stimuli with a frequency of 100 hertz and 2 msec duration. The minimal current of the train that induced fibrillation was taken as the ventricular fibrillation threshold. In seven animals, the effects of stellate stimulation were studied. Ventricular fibrillation threshold was measured during control periods, after 2 minutes of cornoary occlusion, after 2 minutes of stellate stimulation and after 2 minutes of stellate stimulation and coronary occlusion. Coronary occlusion alone decreased ventricular fibrillation threshold an average of 35 percent of control valvues and stellate stimulation alone decreased the threshold an average of 42 percent of control values. The combination of both these interventions decreased ventricular fibrillation threshold an average of 63 percent of control values. The effects of stellate ablation were studied in seven animals. Ventricular fibrillation threshold was measured during control periods, and during coronary occlusion before and after stellate ganglionectomy. Stellectomy increased the threshold an average of 31 percent above control values. After stellectomy, coronary occlusion decreased ventricular fibrillation threshold by only 11 percent of control values, a value 26 percent higher than the threshold during coronary occlusion before stellectomy. These findings may have therapeutic implications for the management of arrhythmias in patients with acute myocardial infarction or some forms of central nervous system disease.
B R Kliks; M J Burgess; J A Abildskov
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  36     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-09-18     Completed Date:  1975-09-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  45-9     Citation Subset:  AIM; IM    
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MeSH Terms
Arrhythmias, Cardiac / physiopathology
Coronary Disease / physiopathology*
Disease Models, Animal
Heart Rate
Myocardial Infarction / mortality
Stellate Ganglion / surgery
Sympathetic Nervous System / physiopathology*
Ventricular Fibrillation / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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