Document Detail


Influence of sympathetic autonomic arousal on cortical arousal: implications for a therapeutic behavioural intervention in epilepsy.
MedLine Citation:
PMID:  15120749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Negative amplitude shifts of cortical potential are related to seizure activity in epilepsy. Regulation of the cortical potential with biofeedback has been successfully used to reduce the frequency of some patients' seizures. Although such behavioural treatments are increasingly popular as an alternative to pharmacotherapy, there has been no investigation of the mechanisms that might bridge the behavioural index of peripheral autonomic activity and the central regulation of arousal. Galvanic Skin Response (GSR) is a sensitive measurement of autonomic arousal and physiological state which reflects one's behaviour. Thus we investigated the effect of peripheral autonomic modulation on cortical arousal with the future intention of using GSR biofeedback as a therapeutic treatment for epilepsy. The cortical negative potential was induced using the paradigm called Contingent Negative Variation (CNV) and measured in different physiological states. A high skin resistance state (reflecting a state of relaxation) and a low skin resistance state (reflecting a state of arousal), were engendered by two opposing procedures of GSR biofeedback. The CNV negative potential, acting as an index of cortical excitation, was significantly greater in amplitude at high levels of skin resistance (relaxed state) than at low levels of skin resistance (aroused state). Our results suggest an inverse relationship between a peripheral measure of autonomic arousal and an index of cortical arousal, the CNV. Moreover, we demonstrate modulation of this arousal-related potential by a behavioural intervention, indicating a potential therapeutic use of arousal biofeedback using GSR in the management of treatment-resistant epilepsy.
Authors:
Yoko Nagai; Laura H Goldstein; Hugo D Critchley; Peter B C Fenwick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epilepsy research     Volume:  58     ISSN:  0920-1211     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-05-03     Completed Date:  2004-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  185-93     Citation Subset:  IM    
Affiliation:
Department of Clinical and Experimental Epilepsy, Institute of Neurology, Box 19, UCL, Queen Square, London WC1N 3BG, UK. y.nagai@ion.ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adrenergic Fibers / physiology
Adult
Analysis of Variance
Arousal / physiology*
Cerebral Cortex / physiology*
Contingent Negative Variation / physiology*
Epilepsy / physiopathology*
Female
Galvanic Skin Response / physiology*
Humans
Male
Middle Aged
Reaction Time / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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