Document Detail


Influence of supercritical CO(2) pressurization on the phase behavior of mixed cholesteryl esters.
MedLine Citation:
PMID:  20654706     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Evidences indicating the presence of phase transformations in the mixed cholesteryl benzoate (CBE) and cholesteryl butyrate (CBU) under the supercritical CO(2) pressurization, by means of differential scanning calorimetry (DSC) and X-ray diffraction (XRD), are presented in this work. These include (1) the DSC heating curve of pure CBU; (2) the DSC heating curves of CBU/CBE mixtures; (3) the XRD spectra of pure CBU; (4) the XRD spectra of CBU/CBE mixtures; (5) CBU and CBE are miscible in either solid phase or liquid phase over the whole composition range. As a result of the presence of these phase transformations induced by pressurization, it could be deduced that a solid solution of the CBU/CBE mixture might have formed at the interfaces under supercritical conditions, subsequently influencing their dissolving behaviors in supercritical CO(2).
Authors:
Zhen Huang; Mei Feng; Junfeng Su; Yuhua Guo; Tie-Yan Liu; Yee C Chiew
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Publication Detail:
Type:  Journal Article     Date:  2010-07-21
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  397     ISSN:  1873-3476     ISO Abbreviation:  Int J Pharm     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  130-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
Tianjin Key Laboratory of Refrigeration Technology, Department of Packaging Engineering, Tianjin University of Commerce, Tianjin 300134, China. huang900@yahoo.com
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