Document Detail

Influence of substance P on carotid sinus nerve baro- and chemoreceptor activity in rabbits.
MedLine Citation:
PMID:  1704614     Owner:  NLM     Status:  MEDLINE    
Substance P (SP) is abundant in the carotid sinus nerve (CSN) and has been implicated in baro- and chemoreceptor reflexes. We examined the effect of SP on blood pressure, heart rate, phrenic nerve activity, hindlimb perfusion pressure, and cardiac contractile strength in urethane-anesthetized rabbits with bilaterally cut cervical sympathetic, vagus, and aortic depressor nerves. Retrograde simultaneous injection of SP (0.5-2.7 micrograms/kg in 0.2-0.3 ml saline) into both carotid sinus areas via the internal carotid arteries decreased blood pressure (by 56%), heart rate (by 13%), cardiac contractility (by 25%) and phrenic nerve activity (by 77%). The effect on hindlimb perfusion pressure was variable. There was both a reflex effect and direct hindlimb vasodilation. In another group of rabbits, the carotid sinus areas were vascularly isolated and perfused with SP (0.19 micrograms/min dissolved in Locke's solution) or Locke's solution alone for 5 min. While carotid sinus perfusion pressure was maintained in the range of 80-120 mmHg, mean arterial blood pressure, heart rate, and unit activity from the CSN were recorded. SP increased the activity of 11 of 18 baroreceptor fibers and inhibited all of 20 chemoreceptor fibers. SP decreased mean arterial blood pressure and heart rate, but the changes were less than those obtained with injection of SP into nonisolated carotid sinus arteries because systemic effects of SP, which in some cases counteracted the reflex effects, were eliminated.
L Qu; S L Stuesse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  11     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1990 Sep-Oct
Date Detail:
Created Date:  1991-03-18     Completed Date:  1991-03-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  955-61     Citation Subset:  IM    
Northeastern Ohio University College of Medicine, Neurobiology Department, Rootstown 44272.
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MeSH Terms
Blood Pressure / drug effects*
Carotid Sinus / innervation*
Chemoreceptor Cells / drug effects*
Hemodynamics / drug effects
Hindlimb / blood supply
Myocardial Contraction / drug effects
Phrenic Nerve / drug effects
Pressoreceptors / drug effects*
Substance P / pharmacology*
Reg. No./Substance:
33507-63-0/Substance P

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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