| Influence of a subinhibitory dose of antifungal fatty acids from Sporothrix flocculosa on cellular lipid composition in fungi. | |
| | |
MedLine Citation:
|
PMID: 8898307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Antifungal fatty acids produced by the biocontrol fungus Sporothrix flocculosa were studied on the basis of their effect on growth and cellular lipid composition of three fungi, Cladosporium cucumerinum, Fusarium oxysporum, and S. flocculosa, whose growth was decreased by 51, 33, and 5%, respectively, when exposed to 0.4 mg fatty acid per ml. The sensitivity to fatty acid antibiotics from S. flocculosa was related to a high degree of unsaturation of phospholipid fatty acids and a low proportion of sterols. The major responses of sensitive fungi to sublethal doses of antifungal fatty acids from liquid culture of S. flocculosa were: (i) a decrease in total lipid; (ii) an increase in the degree of fatty acid unsaturation (18:1 > 18:2 > 18:3); (iii) an increase in free fatty acids and phosphatidic acid and a decrease in total phospholipids; and (iv) an increase in sterol/phospholipid ratio. These modifications in lipid composition led to an increase in membrane fluidity in sensitive fungi as demonstrated by assessment of fluoresence anisotropy using liposomes and 1,6-diphenyl-1,3,5-hexatriene probe. This alteration in the physical state of lipids appears to be responsible for the previously demonstrated alteration of membrane structure and function in fungi confronted to S. flocculosa. |
| | |
Authors:
|
M Benyagoub; C Willemot; R R Bélanger |
Related Documents
:
|
1480157 - Incorporation of radioiodinated fatty acids into cardiac phospholipids of normoxic cani... 856287 - Effects of thiamine and pyridoxine on the lipid composition of saccharomyces carlsberge... 6421507 - Accumulation of unesterified arachidonic acid in ischemic canine myocardium. relationsh... 890867 - Interactions between fluorescent labeled phosphatidyl serine and cations. 18191967 - Peroxisome proliferator-activated receptors and the metabolic syndrome. 18960867 - Differential titrimetric determination of mixtures of selenium and tellurium. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Lipids Volume: 31 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1996 Oct |
Date Detail:
|
Created Date: 1997-02-04 Completed Date: 1997-02-04 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1077-82 Citation Subset: IM |
Affiliation:
|
Department of Plant Science, Faculty of Agriculture and Food Science, Laval University, Quebec, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antifungal Agents
/
pharmacology* Fatty Acids / pharmacology* Fluorescence Polarization Fusarium / drug effects*, growth & development, metabolism Lipid Metabolism* Sporothrix / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Antifungal Agents; 0/Fatty Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effectiveness of resistant starch, compared to guar gum, in depressing plasma cholesterol and enhanc...
Next Document: Ultrasound-assisted synthesis of santalbic acid and a study of triacylglycerol species in Santalum a...