| Influence of the stimulation of carotid body chemoreceptors on the gastric mucosal blood flow in artificially ventilated and spontaneously breathing rats. | |
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MedLine Citation:
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PMID: 12369734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cardiovascular effects of the stimulation of arterial chemoreceptors are different in spontaneously breathing and artificially ventilated animals. Respiratory failure and long term sojourn at high altitude coincide frequently with the occurrence of gastric ulceration. In both these situations a profound stimulation of arterial chemoreceptors is present. The purpose of the paper was to investigate the reflex effect of stimulation carotid chemoreceptors on gastric mucosal blood flow in the rat. Arterial chemoreceptors were stimulated by two methods (I) substitution gas mixture of 10% oxygen in nitrogen for room air and (II) direct injection of acid saline ( 0.05 ml, pH = 6.8) into the distal part of left common carotid artery. In artificially ventilated rats stimulation of arterial chemoreceptors caused significant increase in gastric mucosal vascular resistance, accompanied by marked decline in blood flow. This effect was mediated by adrenergic mechanism. On the contrary to artificially ventilated rats, decline of gastric mucosal vascular resistance with concomitant increase in blood flow was found in spontaneously breathing animals. This effect was not abolished either by phentolamine or atropine. As vasodilatatory effect of arterial chemoreceptors stimulation was abolished by bilateral vagotomy, we postulate that non adrenergic and non cholinergic vagal fibers mediate observed vascular changes in gastric mucosa in spontaneously breathing rats. We hypothesize that in artificially ventilated patients with respiratory failure stimulation of arterial chemoreceptors by hypoxemia and or acidosis may contribute to the development of gastric mucosal lesions. |
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Authors:
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M Siński; P Kowalczyk; A Stolarczyk; L Sawionek; J Przybylski |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 53 ISSN: 0867-5910 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-10-08 Completed Date: 2003-03-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 359-69 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine and Hypertension, Medical University of Warsaw, Poland. msinski@amwaw.edu.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acids
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pharmacology Animals Carotid Body / drug effects, physiology* Chemoreceptor Cells / drug effects, physiology* Gastric Mucosa / blood supply* Male Oxygen / pharmacology Rats Rats, Wistar Reference Values Regional Blood Flow / drug effects, physiology Respiration, Artificial* Sodium Chloride / pharmacology Vagotomy Vascular Resistance / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Acids; 7647-14-5/Sodium Chloride; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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