Document Detail


Influence of steroid hormones on the carcinogenicity of 90Sr.
MedLine Citation:
PMID:  1070217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Groups of female CBA-mice were given 90Sr (14.8 kBq/g-0.4muCi/g--bodyweight) alone or in combination with polyestrodiolphosphate, methylprednisolone or nortestosterone, respectively. When 90Sr was given in the first combination, the frequency of osteosarcomas was significantly increased whereas the tumour latency time was decreased compared to mice given 90Sr alone. In combination with nortestosterone such effects were not found, whereas the combination 90Sr + methylprednisolone resulted in a strong reduction of the osteosarcoma incidence and a prolonged tumour latency time. The latter experiment was repeated in a larger experiment whereby the results were confirmed.
Authors:
A Nilsson; A Broomé-Karlsson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta radiologica: therapy, physics, biology     Volume:  15     ISSN:  0567-8064     ISO Abbreviation:  Acta Radiol Ther Phys Biol     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1977-02-24     Completed Date:  1977-02-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000201     Medline TA:  Acta Radiol Ther Phys Biol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  417-26     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Neoplasms / drug therapy,  etiology*
Cocarcinogenesis
Estradiol*
Female
Methylprednisolone* / therapeutic use
Mice
Mice, Inbred CBA
Nandrolone*
Neoplasms, Experimental / drug therapy,  etiology
Neoplasms, Radiation-Induced* / drug therapy
Osteosarcoma / drug therapy,  etiology
Strontium Radioisotopes*
Time Factors
Chemical
Reg. No./Substance:
0/Strontium Radioisotopes; 434-22-0/Nandrolone; 50-28-2/Estradiol; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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