| Influence of steroid hormones on the carcinogenicity of 90Sr. | |
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MedLine Citation:
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PMID: 1070217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Groups of female CBA-mice were given 90Sr (14.8 kBq/g-0.4muCi/g--bodyweight) alone or in combination with polyestrodiolphosphate, methylprednisolone or nortestosterone, respectively. When 90Sr was given in the first combination, the frequency of osteosarcomas was significantly increased whereas the tumour latency time was decreased compared to mice given 90Sr alone. In combination with nortestosterone such effects were not found, whereas the combination 90Sr + methylprednisolone resulted in a strong reduction of the osteosarcoma incidence and a prolonged tumour latency time. The latter experiment was repeated in a larger experiment whereby the results were confirmed. |
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Authors:
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A Nilsson; A Broomé-Karlsson |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta radiologica: therapy, physics, biology Volume: 15 ISSN: 0567-8064 ISO Abbreviation: Acta Radiol Ther Phys Biol Publication Date: 1976 Oct |
Date Detail:
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Created Date: 1977-02-24 Completed Date: 1977-02-24 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0000201 Medline TA: Acta Radiol Ther Phys Biol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 417-26 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Neoplasms / drug therapy, etiology* Cocarcinogenesis Estradiol* Female Methylprednisolone* / therapeutic use Mice Mice, Inbred CBA Nandrolone* Neoplasms, Experimental / drug therapy, etiology Neoplasms, Radiation-Induced* / drug therapy Osteosarcoma / drug therapy, etiology Strontium Radioisotopes* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Strontium Radioisotopes; 434-22-0/Nandrolone; 50-28-2/Estradiol; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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