Document Detail

Influence of steroid aerosol treatments on the clearance of inhaled gold particles.
MedLine Citation:
PMID:  694965     Owner:  NLM     Status:  MEDLINE    
Female Long Evans rats were used to test the hypothesis that in haled triamcinolone acetonide accelerates the rate of clearance of particles from the lung. Three groups of animals inhaled a radioactive gold aerosol, which functioned as a tracer of respiratory tract clearance, and then were subjected to various inhalation treatments. The group treated with triamcinolone acetonide aerosol showed a significant acceleration in the rate of early clearance, but the total amount of tracer particles cleared in the first day was not significantly increased. Inhaled triamcinolone acetonide appears to accelerate the translocation of foriegn particles from small airways to larger ones, but stimulation of clearance does not appear to be a large effect.
J C Elliot; R F Phalen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Steroids     Volume:  31     ISSN:  0039-128X     ISO Abbreviation:  Steroids     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-11-22     Completed Date:  1978-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  761-9     Citation Subset:  IM    
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MeSH Terms
Drug Interactions
Gold / metabolism*
Time Factors
Triamcinolone Acetonide / pharmacology*
Reg. No./Substance:
0/Aerosols; 7440-57-5/Gold; 76-25-5/Triamcinolone Acetonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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