Document Detail

Influence of statin treatment on coronary atherosclerosis visualised using multidetector computed tomography.
MedLine Citation:
PMID:  20640900     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Coronary angiography using multidetector computed tomography (MDCT) allows non-invasive assessment of non-calcified, calcified and mixed plaques. Progression of coronary plaques may be influenced by statins.
METHODS: Sixty-three consecutive patients underwent MDCT as a follow-up to their original CT angiography in a retrospective longitudinal study. MDCT was performed by using a voxel size of 0.5 × 0.35 × 0.35 mm(3) at two time points 25 ± 3 months apart. Non-calcified, calcified and mixed coronary plaque components were analysed by using volumetric measurement. The influence of statin, low-density lipoprotein (LDL) and risk factors was assessed by using a linear random intercept model for plaque growth.
RESULTS: The volumes of non-calcified, calcified and mixed coronary plaques significantly (P < 0.001) increased from baseline (medians/interquartile ranges = 21/15-39, 7/3-20 and 36/16-69 mm(3)) to follow-up (29/17-44, 13/6-29 and 41/20-75 mm(3)). Statins significantly slowed the growth of non-calcified plaques (statin coefficient β = -0.0036, P = 0.01) but did not significantly affect the growth rate of mixed or calcified plaques. The effect of statin treatment on non-calcified plaques remained significant after adjusting for LDL levels and cardiac risk factors.
CONCLUSION: Quantification using MDCT shows that progression of non-calcified coronary plaques may be slowed by statins.
Hans Hoffmann; Katja Frieler; Peter Schlattmann; Bernd Hamm; Marc Dewey
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-18
Journal Detail:
Title:  European radiology     Volume:  20     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-11     Completed Date:  2011-03-25     Revised Date:  2011-07-14    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2824-33     Citation Subset:  IM    
Department of Radiology, Charité, Medical School, Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
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MeSH Terms
Coronary Angiography / methods*
Coronary Artery Disease / drug therapy*,  radiography*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Middle Aged
Tomography, X-Ray Computed / methods*
Treatment Outcome
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors
Erratum In:
Eur Radiol. 2011 Jul;21(7):1576

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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