Document Detail


Influence of a standard meal on the absorption of a controlled release pseudoephedrine suspension.
MedLine Citation:
PMID:  3395668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of a standard meal on the extent and rate of absorption of pseudoephedrine from a liquid controlled release (CR) formulation (Pennkinetic System) was studied in 16 normal male volunteers. Equivalent single doses of an immediate release reference syrup (IR-Sudafed) and the CR suspension were each studied under both fasted and postprandial conditions. AUC results showed no significant influence of food or formulation, indicating that the CR formulation was absorbed to the same extent as the IR product under all conditions. CMAX and TMAX tabulations under fasted conditions indicated that the CR preparation peaked at a lower level at a later time. Food diminished IR CMAXs but the CR suspension's CMAXs and TMAXs were apparently unaffected by food. This study indicates that this CR pseudoephedrine suspension releases drug independently of food intake.
Authors:
D A Graves; M T Wecker; M C Meyer; A B Straughn; L P Amsel; O N Hinsvark; A K Bhargava; K S Rotenberg
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Biopharmaceutics & drug disposition     Volume:  9     ISSN:  0142-2782     ISO Abbreviation:  Biopharm Drug Dispos     Publication Date:    1988 May-Jun
Date Detail:
Created Date:  1988-09-08     Completed Date:  1988-09-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911226     Medline TA:  Biopharm Drug Dispos     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  267-72     Citation Subset:  IM    
Affiliation:
Pennwalt Pharmaceutical Division, Rochester, NY 14603.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Delayed-Action Preparations
Ephedrine / administration & dosage,  adverse effects,  pharmacokinetics*
Food*
Humans
Male
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 299-42-3/Ephedrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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