| Influence of a standard meal on the absorption of a controlled release pseudoephedrine suspension. | |
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MedLine Citation:
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PMID: 3395668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of a standard meal on the extent and rate of absorption of pseudoephedrine from a liquid controlled release (CR) formulation (Pennkinetic System) was studied in 16 normal male volunteers. Equivalent single doses of an immediate release reference syrup (IR-Sudafed) and the CR suspension were each studied under both fasted and postprandial conditions. AUC results showed no significant influence of food or formulation, indicating that the CR formulation was absorbed to the same extent as the IR product under all conditions. CMAX and TMAX tabulations under fasted conditions indicated that the CR preparation peaked at a lower level at a later time. Food diminished IR CMAXs but the CR suspension's CMAXs and TMAXs were apparently unaffected by food. This study indicates that this CR pseudoephedrine suspension releases drug independently of food intake. |
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Authors:
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D A Graves; M T Wecker; M C Meyer; A B Straughn; L P Amsel; O N Hinsvark; A K Bhargava; K S Rotenberg |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Biopharmaceutics & drug disposition Volume: 9 ISSN: 0142-2782 ISO Abbreviation: Biopharm Drug Dispos Publication Date: 1988 May-Jun |
Date Detail:
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Created Date: 1988-09-08 Completed Date: 1988-09-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7911226 Medline TA: Biopharm Drug Dispos Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 267-72 Citation Subset: IM |
Affiliation:
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Pennwalt Pharmaceutical Division, Rochester, NY 14603. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Delayed-Action Preparations Ephedrine / administration & dosage, adverse effects, pharmacokinetics* Food* Humans Male |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 299-42-3/Ephedrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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