Document Detail

Influence of a standard meal on the absorption of a controlled release pseudoephedrine suspension.
MedLine Citation:
PMID:  3395668     Owner:  NLM     Status:  MEDLINE    
The influence of a standard meal on the extent and rate of absorption of pseudoephedrine from a liquid controlled release (CR) formulation (Pennkinetic System) was studied in 16 normal male volunteers. Equivalent single doses of an immediate release reference syrup (IR-Sudafed) and the CR suspension were each studied under both fasted and postprandial conditions. AUC results showed no significant influence of food or formulation, indicating that the CR formulation was absorbed to the same extent as the IR product under all conditions. CMAX and TMAX tabulations under fasted conditions indicated that the CR preparation peaked at a lower level at a later time. Food diminished IR CMAXs but the CR suspension's CMAXs and TMAXs were apparently unaffected by food. This study indicates that this CR pseudoephedrine suspension releases drug independently of food intake.
D A Graves; M T Wecker; M C Meyer; A B Straughn; L P Amsel; O N Hinsvark; A K Bhargava; K S Rotenberg
Related Documents :
2591418 - Chronopharmacokinetic and bioequivalence studies of two formulations of trimipramine af...
11879748 - Preparation, characterization, and tabletting properties of a new cellulose-based pharm...
19869178 - The physiological variations in resistance to bile flow to the intestine.
2598978 - Effect of food on the absorption and pharmacokinetics of prednisolone from enteric-coat...
12647798 - In vitro acute toxicity of anionic surfactant linear alkylbenzene sulphonate (las) on t...
16701908 - Effects of manganese on chemically induced food search behaviour of the norway lobster,...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Biopharmaceutics & drug disposition     Volume:  9     ISSN:  0142-2782     ISO Abbreviation:  Biopharm Drug Dispos     Publication Date:    1988 May-Jun
Date Detail:
Created Date:  1988-09-08     Completed Date:  1988-09-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911226     Medline TA:  Biopharm Drug Dispos     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  267-72     Citation Subset:  IM    
Pennwalt Pharmaceutical Division, Rochester, NY 14603.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Delayed-Action Preparations
Ephedrine / administration & dosage,  adverse effects,  pharmacokinetics*
Reg. No./Substance:
0/Delayed-Action Preparations; 299-42-3/Ephedrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of acute water deprivation on renal function in rats.
Next Document:  Changes in salicylate serum concentration and metabolism during chronic dosing in normal volunteers.