Document Detail

Influence of the stage of pregnancy on gentamicin disposition in the ewe.
MedLine Citation:
PMID:  1610078     Owner:  NLM     Status:  MEDLINE    
The influence of the state of pregnancy (mid- and end of pregnancy) on the kinetic disposition of gentamicin was determined in the ewe. Kinetic parameters were determined after a single intravenous bolus administration (4 mg/kg). It was shown that the steady state volume of distribution was significantly increased from mid to end of pregnancy (from 0.09 to 0.194 Similarly, plasma clearance was increased by about 150% at the end of pregnancy. These modifications must be taken into account in order to adapt the dosage regimen and determine a withdrawal time for gentamicin.
M Oukessou; P L Toutain
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annales de recherches vétérinaires. Annals of veterinary research     Volume:  23     ISSN:  0003-4193     ISO Abbreviation:  Ann. Rech. Vet.     Publication Date:  1992  
Date Detail:
Created Date:  1992-07-22     Completed Date:  1992-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1267230     Medline TA:  Ann Rech Vet     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Département de Physiologie et Thérapeutique, Institut Agronomique et Vétérinaire Hassan II, Rabat, Morocco.
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MeSH Terms
Gentamicins / pharmacokinetics*
Pregnancy, Animal / metabolism*
Sheep / metabolism*
Tissue Distribution
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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