Document Detail


Influence of spontaneous hypertension and cardiac hypertrophy on the severity of ischemic arrhythmias in the rat.
MedLine Citation:
PMID:  2976594     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac hypertrophy (CH) and hypertension (HT) are major determinants of sudden cardiac death in patients with coronary artery disease. To investigate the hypothesis that CH and HT increase the incidence of severe ventricular arrhythmias in an animal model, we performed a 30-min period of coronary artery ligation in anesthetized spontaneously hypertensive rats (SHR), normotensive Wistar Kyoto (WKY) and Wistar (W) rats. The incidence and duration of ventricular fibrillation resulting from coronary artery occlusion were significantly (p less than 0.01) increased in hypertensive rats compared to normotensive animals. The calcium entry blocker nicardipine was administered orally to SHR either chronically for 8 weeks (20 mg.kg-1 twice daily) or acutely as a single dose of 20 mg.kg-1. After long-term treatment with nicardipine, left ventricular hypertrophy index and systolic blood pressure were significantly (p less than 0.001) reduced when compared to vehicle-treated SHR, whereas a single administration of nicardipine only decreased blood pressure without affecting cardiac mass. In the long-term nicardipine-treated SHR group, acute coronary artery ligation induced significantly less ventricular fibrillation (p less than 0.05) and mortality (p less than 0.001) than in acutely nicardipine-treated or untreated SHR groups. In conclusion, the data suggest that the severity and incidence of lethal ventricular arrhythmias are more elevated in hypertensive than in normotensive rats and this may be related to the myocardial hypertrophic state.
Authors:
P Bélichard; D Pruneau; L Rochette
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Basic research in cardiology     Volume:  83     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1988 Sep-Oct
Date Detail:
Created Date:  1989-04-14     Completed Date:  1989-04-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  560-6     Citation Subset:  IM    
Affiliation:
Centre de Recherche, Laboratoires Fournier S.A., Dijon, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomegaly / complications*
Coronary Disease / complications*,  drug therapy
Hypertension / complications*
Models, Cardiovascular
Nicardipine / therapeutic use
Rats
Rats, Inbred SHR
Rats, Inbred Strains
Rats, Inbred WKY
Ventricular Fibrillation / etiology*
Chemical
Reg. No./Substance:
55985-32-5/Nicardipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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