| Influence of spontaneous hypertension and cardiac hypertrophy on the severity of ischemic arrhythmias in the rat. | |
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MedLine Citation:
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PMID: 2976594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac hypertrophy (CH) and hypertension (HT) are major determinants of sudden cardiac death in patients with coronary artery disease. To investigate the hypothesis that CH and HT increase the incidence of severe ventricular arrhythmias in an animal model, we performed a 30-min period of coronary artery ligation in anesthetized spontaneously hypertensive rats (SHR), normotensive Wistar Kyoto (WKY) and Wistar (W) rats. The incidence and duration of ventricular fibrillation resulting from coronary artery occlusion were significantly (p less than 0.01) increased in hypertensive rats compared to normotensive animals. The calcium entry blocker nicardipine was administered orally to SHR either chronically for 8 weeks (20 mg.kg-1 twice daily) or acutely as a single dose of 20 mg.kg-1. After long-term treatment with nicardipine, left ventricular hypertrophy index and systolic blood pressure were significantly (p less than 0.001) reduced when compared to vehicle-treated SHR, whereas a single administration of nicardipine only decreased blood pressure without affecting cardiac mass. In the long-term nicardipine-treated SHR group, acute coronary artery ligation induced significantly less ventricular fibrillation (p less than 0.05) and mortality (p less than 0.001) than in acutely nicardipine-treated or untreated SHR groups. In conclusion, the data suggest that the severity and incidence of lethal ventricular arrhythmias are more elevated in hypertensive than in normotensive rats and this may be related to the myocardial hypertrophic state. |
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Authors:
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P Bélichard; D Pruneau; L Rochette |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Basic research in cardiology Volume: 83 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 1988 Sep-Oct |
Date Detail:
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Created Date: 1989-04-14 Completed Date: 1989-04-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 560-6 Citation Subset: IM |
Affiliation:
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Centre de Recherche, Laboratoires Fournier S.A., Dijon, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiomegaly / complications* Coronary Disease / complications*, drug therapy Hypertension / complications* Models, Cardiovascular Nicardipine / therapeutic use Rats Rats, Inbred SHR Rats, Inbred Strains Rats, Inbred WKY Ventricular Fibrillation / etiology* |
| Chemical | |
Reg. No./Substance:
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55985-32-5/Nicardipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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