Document Detail

Influence of splenectomy, partial splenectomy and splenic artery ligation on E. coli sepsis in rats.
MedLine Citation:
PMID:  2688347     Owner:  NLM     Status:  MEDLINE    
Male Sprague-Dawley rats were allocated to four groups--sham operation, partial splenectomy, splenic artery ligation or total splenectomy, and 4 weeks after the operation 3 x 10(8) colony-forming units of Escherichia coli were injected intraperitoneally. Among the splenectomized rats the mortality was significantly (p less than 0.02) increased compared with the controls, while both partial splenectomy and splenic artery ligation did not influence survival. Blood clearance and organ (liver, spleen and lungs) uptake of intravenously injected, radiolabelled, heat-killed E. coli were determined 1 hour after the intraperitoneal challenge. Splenectomy caused a significant decrease in blood clearance. Splenic uptake of radiolabelled E. coli was significantly reduced following partial splenectomy and splenic artery ligation. The splenic operations increased hepatic uptake expressed per gram tissue. Splenectomy thus resulted in reduced blood clearance and increased mortality in Gram-negative sepsis, while the reduced splenic uptake following partial splenectomy or splenic artery ligation did not influence blood clearance of E. coli or mortality.
R Andersson; S Bengmark
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta chirurgica Scandinavica     Volume:  155     ISSN:  0001-5482     ISO Abbreviation:  Acta Chir Scand     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1990-01-23     Completed Date:  1990-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906530     Medline TA:  Acta Chir Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  451-4     Citation Subset:  IM    
Department of Surgery, Lund University, Sweden.
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MeSH Terms
Escherichia coli Infections / etiology,  mortality*
Rats, Inbred Strains
Sepsis / etiology,  mortality*
Splenectomy / adverse effects*
Splenic Artery / physiology*

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