Document Detail

Influence of sotalol on the time constant of isovolumic left ventricular relaxation in anesthetized dogs.
MedLine Citation:
PMID:  10376899     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effects of various doses of sotalol on myocardial relaxation in healthy dogs. ANIMALS: 12 healthy adult mixed-breed dogs anesthetized with thiopental and alpha-chloralose. PROCEDURES: Left ventricular pressure (LVP), aortic pressure, and aortic flow velocity were measured. The time constant of isovolumic relaxation (tau) was determined by means of linear regression of the natural logarithm of LVP and by means of direct measurement from the LVP-versus-time curve. Sotalol was administered IV at cumulative doses of 1, 2, 4, and 8 mg/kg to 6 dogs; the other 6 were used as controls. Mean systolic aortic pressure was used to assess afterload, and maximal rate of increase in LVP versus time (dP/dt) was used as an index of contractility. RESULTS: After administration of the first dose of sotalol, tau was increased significantly, and maximum dP/dt was decreased significantly, compared with baseline values. Administration of additional doses of sotalol did not result in any additional change in tau, but maximum dP/dt increased, and maximum dP/dt after administration of the final dose of sotalol was significantly higher than maximum dP/dt after administration of the first dose. There were no significant changes in mean systolic aortic pressure. CONCLUSIONS AND CLINICAL RELEVANCE: In healthy dogs, sotalol did not have any negative effect on myocardial relaxation beyond those attributable to its beta-blocking properties, despite an increase in intracellular ionized calcium concentration, as suggested by an increase in maximum dP/dt after an initial decrease.
R W Seidler; K Mueller; T Nakayama; R L Hamlin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of veterinary research     Volume:  60     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-08-03     Completed Date:  1999-08-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  717-21     Citation Subset:  IM    
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA.
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MeSH Terms
Anesthesia, General
Dose-Response Relationship, Drug
Myocardial Contraction / drug effects*,  physiology
Regression Analysis
Sotalol / pharmacology*
Systole / drug effects
Ventricular Function, Left / drug effects,  physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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