Document Detail

Influence of some inflammatory or antiinflammatory substances on skin biopsies investigated with microcalorimetry and respiratory techniques.
MedLine Citation:
PMID:  883847     Owner:  NLM     Status:  MEDLINE    
Thermal effects were achieved from skin biopsies (epidermis, corium, subcutis) measured by batch-microcalorimetry, after exposure to potent inflammatory or antiinflammatory substances (compound 48/80, histamine, serotonine and hydrocortisone phosphate). Exothermic effects were achieved from 48-80, histamine and hydrocortisone phosphate, when exposed to the skin and lasting for varying time. From serotonine initial endothermic signals were achieved but after about 50 min there was stabilizing of the thermal reaction at the baseline. To analyze the nature of these non-specific thermal effects, determinations of O2 consumption and CO2 production were performed, using Warburg technique on exactly matched tissue pieces exposed to the same substances and run parallely with the microcalorimetrical determinations. An increased respiration, probably as an indicator of increased metabolism was registrated for all test substances acting on the skin. It felt, that the thermal effects reflect an increased metabolism of the tissue exposed to the test substances.
L Hellgren; K Larsson; J Vincent
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives for dermatological research. Archiv für dermatologische Forschung     Volume:  258     ISSN:  -     ISO Abbreviation:  Arch Dermatol Res     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-09-17     Completed Date:  1977-09-17     Revised Date:  2014-07-21    
Medline Journal Info:
Nlm Unique ID:  7512589     Medline TA:  Arch Dermatol Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  295-303     Citation Subset:  IM    
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MeSH Terms
Basal Metabolism / drug effects
Calorimetry / methods
Histamine / pharmacology*
Hydrocortisone / pharmacology*
Oxygen Consumption / drug effects
Serotonin / pharmacology*
Skin / anatomy & histology,  drug effects*,  metabolism
Skin Temperature / drug effects
p-Methoxy-N-methylphenethylamine / pharmacology*
Reg. No./Substance:
333DO1RDJY/Serotonin; 4091-50-3/p-Methoxy-N-methylphenethylamine; 820484N8I3/Histamine; WI4X0X7BPJ/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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