Document Detail

Influence of sodium metabisulfite and glutathione on the stability of vitamin C in O/W emulsion and extemporaneous aqueous gel.
MedLine Citation:
PMID:  16806754     Owner:  NLM     Status:  MEDLINE    
Vitamin C exerts several functions on skin as collagen synthesis, depigmentant and antioxidant activity. Vitamin C is unstable in the presence of oxygen, luminosity, humidity, high temperatures and heavy metals, which presents a significant challenge to the development of cosmetic formulations. Therefore, the utilization of an effective antioxidant system is required to maintain the vitamin C stability. The purpose of this research work was to develop prototypes of cosmetic formulations, as O/W emulsion and extemporaneous aqueous gel, containing vitamin C and to evaluate the influence of sodium metabisulfite (SMB) and glutathione (GLT), as antioxidants, on the stability of the active substance. A HPLC stability-indicating method was developed and validated for this study and stability assays were performed in 90 and 26 days and storage conditions were 5.0+/-0.5, 24+/-2 and 40.0+/-0.5 degrees C. The HPLC stability-indicating method showed linearity (r(2)>0.99), specificity, R.S.D.<1.22% and accuracy/recovery ranging from 95.46 to 101.54%. Preparations with SMB or GLT and the antioxidant-free presented results statistically distinct, demonstrating the necessity of the antioxidant system addition. O/W emulsions with SMB or GLT retained the vitamin C content >90.38% stored at 5.0+/-0.5 and 24+/-2 degrees C. For the aqueous gel with SMB or GLT, the active substance concentration was maintained >94.03%. Considering the vitamin C stability, the SMB and the GLT showed to be statistically adequate, as antioxidants, for the cosmetic formulations.
Adriana M Maia; André Rolim Baby; Claudinéia A S O Pinto; Wilson J Yasaka; Eunice Suenaga; Telma M Kaneko; Maria Valéria Robles Velasco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-26
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  322     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-11     Completed Date:  2006-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  130-5     Citation Subset:  IM    
Laboratory of Cosmetology, Department of Pharmacy, School of Pharmaceutical Sciences, University of São Paulo, 580 Prof. Lineu Prestes Av., bl. 13, Conjunto das Químicas, Cidade Universitária, 05508-900 São Paulo, SP, Brazil.
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MeSH Terms
Antioxidants / chemistry*
Ascorbic Acid / analysis,  chemistry*
Drug Stability
Glutathione / chemistry*
Oils / chemistry
Sulfites / chemistry*
Water / chemistry
Reg. No./Substance:
0/Antioxidants; 0/Emulsions; 0/Gels; 0/Oils; 0/Sulfites; 50-81-7/Ascorbic Acid; 70-18-8/Glutathione; 7681-57-4/sodium metabisulfite; 7732-18-5/Water

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