Document Detail


Influence of smooth muscle tone and longitudinal tension on the collapsibility of immature airways.
MedLine Citation:
PMID:  3194153     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mechanical properties and pressure-flow relationships of tracheae excised from very premature lambs were studied in a plethysmograph. Control (Group I) data revealed the tracheae to be extremely compliant, collapsible airways, with an inflation compliance (Si) of 0.033 (+/- 0.004 SE) mmHg-1, collapsing compliance (Sc) of 0.026 (+/- 0.001 SE) mmHg-1, and pressure-flow relationships similar to those of a Starling resistor. Acetylcholine administration (Group II) lowered both Si, 0.026 (+/- 0.003 SE) mmHg-1 and Sc, 0.022 (+/- SE) mmHg-1, as did longitudinal stretch (Group III): Si, 0.021 (+/- .003 SE) mmHg-1, and Sc, 0.017 (+/- 0.002 SE) mmHg-1. Alterations in tracheal collapsibility were also evidenced by significant reductions in resistance to airflow when the tracheae were subjected to compressive forces. Altering both smooth muscle tone (acetylcholine administration) and longitudinal length simultaneously (Group IV) produced results similar to those obtained for Group III. These data help to define the functional characteristics of immature airways and may provide insight for more effective clinical management of the premature infant.
Authors:
R B Penn; M R Wolfson; T H Shaffer
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  5     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  1988  
Date Detail:
Created Date:  1988-12-29     Completed Date:  1988-12-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  132-8     Citation Subset:  IM    
Affiliation:
Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Airway Resistance* / drug effects
Animals
Humans
Infant, Newborn
Infant, Premature
Muscle, Smooth / drug effects,  physiology*
Plethysmography
Pressure
Pulmonary Ventilation
Sheep
Trachea / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
HL 32031/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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