Document Detail

Influence of smoking status on cough reflex sensitivity in subjects with COPD.
MedLine Citation:
PMID:  18949517     Owner:  NLM     Status:  MEDLINE    
Cough reflex sensitivity has not been studied extensively in patients with chronic obstructive pulmonary disease (COPD). The aim of the study was to evaluate cough reflex sensitivity to capsaicin in current and former smokers with COPD and examine its association with potentially protussive mediators. Fifteen active smokers and 18 ex-smokers with moderate to severe COPD, 14 healthy active smokers, and 13 healthy never smokers were enrolled. Capsaicin aerosol was administered in order of ascending concentration until the concentrations inducing two or more coughs (C(2)) and five or more coughs (C(5)) were attained. The concentrations of leukotriene E(4) (LTE(4)), leukotriene B(4) (LTB(4)), and interleukin-8 (IL-8) in bronchoalveolar lavage (BAL) fluid were analyzed by ELISA. Cough reflex sensitivity in COPD smokers [mean log C(2) = 1.20 +/- 0.23 (SEM) microM; log C(5) = 1.85 +/- 0.21 microM] did not differ from that in COPD ex-smokers (log C(2) = 1.15 +/- 0.14 microM; log C(5) = 2.10 +/- 0.19 microM; p > 0.05). Mean C(2) and C(5) in both COPD groups were significantly lower than in healthy active smokers, but higher compared with the healthy never-smokers. BAL fluid concentrations of LTE(4) and LTB(4) were similar in all groups. IL-8 concentrations did not differ between COPD smokers, COPD ex-smokers, and healthy active smokers, but were significantly higher in all three groups compared with healthy never smokers. Cough reflex sensitivity to capsaicin does not differ between smokers and ex-smokers with COPD.
Kristina Stravinskaite; Brigita Sitkauskiene; Peter V Dicpinigaitis; Agne Babusyte; Raimundas Sakalauskas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-24
Journal Detail:
Title:  Lung     Volume:  187     ISSN:  0341-2040     ISO Abbreviation:  Lung     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
Department of Pulmonology and Immunology, Kaunas University of Medicine, Eiveniu 2, Kaunas, LT 50009, Lithuania.
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MeSH Terms
Administration, Inhalation
Bronchoalveolar Lavage Fluid
Capsaicin / administration & dosage*,  adverse effects
Case-Control Studies
Cough / physiopathology*
Dose-Response Relationship, Drug
Interleukin-8 / metabolism
Leukotriene B4 / metabolism
Leukotriene E4 / metabolism
Middle Aged
Pulmonary Disease, Chronic Obstructive / metabolism,  physiopathology*
Reflex / physiology*
Respiratory Hypersensitivity / chemically induced,  metabolism*
Sensory System Agents / administration & dosage*,  adverse effects
Smoking / physiopathology*
Reg. No./Substance:
0/Interleukin-8; 0/Sensory System Agents; 404-86-4/Capsaicin; 71160-24-2/Leukotriene B4; 75715-89-8/Leukotriene E4

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