| Influence of sleep on anal sphincteric pressure in health and after ileal pouch-anal anastomosis. | |
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MedLine Citation:
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PMID: 1735315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fecal incontinence at night may be a disturbing consequence of ileal pouch-anal anastomosis (IPAA). The hypothesis was that decreases in anal canal resting pressure occur as sleep deepens and that the decreases are more profound in pouch patients with incontinence than in controls. Using a sleeve catheter assembly for recording intraluminal and canal pressure and polysomnographic recordings of sleep stages, progressive decreases in anal canal resting pressure with deepening sleep occurred in 11 healthy controls (mean +/- SEM: 57 +/- 3 mm Hg to 43 +/- 3 mm Hg: P less than 0.05) and in 11 patients after IPAA (55 +/- 3 mm Hg to 42 +/- 4 mm Hg; P less than 0.05). Minute-to-minute variations in mean pressure were also found in both controls and IPAA patients, and they were greater at night in patients (P less than 0.05), except during rapid eye movement (REM) sleep. In three patients, resting pressure during REM sleep decreased markedly to 31 +/- 8 mm Hg. This decrease plus the variations in pressure during REM sleep led to incontinence. In conclusion, decreases in anal resting pressure coupled with marked minute-to-minute variations in pressure during sleep occurred in controls and in patients after IPAA and, when profound, led to nocturnal fecal incontinence in some patients. |
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Authors:
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B A Orkin; N J Soper; K A Kelly; J Dent |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Diseases of the colon and rectum Volume: 35 ISSN: 0012-3706 ISO Abbreviation: Dis. Colon Rectum Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-03-12 Completed Date: 1992-03-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372764 Medline TA: Dis Colon Rectum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 137-44 Citation Subset: IM |
Affiliation:
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Department of Surgery, Mayo Clinic, Rochester, Minnesota. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anal Canal / physiology*, physiopathology Fecal Incontinence / etiology, physiopathology Female Humans Male Middle Aged Pressure Proctocolectomy, Restorative* / adverse effects Sleep / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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DK18278/DK/NIDDK NIH HHS; DK34988/DK/NIDDK NIH HHS; RR585/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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