Document Detail

Influence of simvastatin on bone regeneration of tibial defects and blood cholesterol level in rats.
MedLine Citation:
PMID:  17262137     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate the effects of simvastatin, by oral or subcutaneous administration, on tibial defects regeneration and blood cholesterol level in rats. A surgical defect was made on the right tibia of 40 male animals assigned to 4 groups (n=10), based on two routes of administration and on the use or not of simvastatin: subcutaneous injection of simvastatin (7 mg/kg) (group AT) or only the vehicle of drug suspension (group AC), above the defect area, for 5 days; and 20 mg/kg of simvastatin macerated on water (group BT) or only water (group BC), orally, daily, during the whole observation period. The animals were sacrificed after 15 or 30 days, when blood samples were analyzed to check plasma cholesterol levels. Tibiae were removed and, after decalcification and routine laboratorial processing, histological and histomorphometrical analyses were carried out. ANOVA was used for statistical analysis at 5% significance level. The histological and histomorphometrical analyses showed significant differences only between the experimental periods (p<0.05). Animals sacrificed after 30 days showed better bone repair (p<0.05). There was no statistically significant difference (p>0.05) for blood cholesterol levels between the groups. In conclusion, simvastatin administration either orally or subcutaneously did not improve bone repair of experimental tibial defects and did not alter blood cholesterol levels in rats.
Ana Lia Anbinder; Juliana Campos Junqueira; Maria Nadir G Mancini; Ivan Balducci; Rosilene Fernandes da Rocha; Yasmin Rodarte Carvalho
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brazilian dental journal     Volume:  17     ISSN:  0103-6440     ISO Abbreviation:  Braz Dent J     Publication Date:  2006  
Date Detail:
Created Date:  2007-01-30     Completed Date:  2007-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214652     Medline TA:  Braz Dent J     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  267-73     Citation Subset:  D    
Department of Dentistry, University of Taubaté, Rua dos Operários 9, 12020-270 Taubaté, SP, Brazil.
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MeSH Terms
Administration, Oral
Anticholesteremic Agents / administration & dosage,  therapeutic use*
Bone Diseases / drug therapy*,  pathology
Bone Regeneration / drug effects*
Bone Remodeling / drug effects
Cholesterol / blood*
Chromogenic Compounds / diagnostic use
Injections, Subcutaneous
Osteoblasts / drug effects,  pathology
Osteocytes / drug effects,  pathology
Osteogenesis / drug effects
Periosteum / drug effects,  pathology
Rats, Wistar
Simvastatin / administration & dosage,  therapeutic use*
Tibia / drug effects*,  pathology
Time Factors
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Chromogenic Compounds; 57-88-5/Cholesterol; 79902-63-9/Simvastatin

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