| Influence of sildenafil on lung diffusion during exposure to acute hypoxia at rest and during exercise in healthy humans. | |
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MedLine Citation:
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PMID: 18369657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to determine the influence of sildenafil on the diffusing capacity of the lungs for carbon monoxide (DLCO) and the components of DLCO (pulmonary capillary blood volume VC, and alveolar-capillary membrane conductance DM) at rest and following exercise with normoxia and hypoxia. This double-blind placebo-controlled, cross-over study included 14 healthy subjects (age = 33 +/- 11 years, ht = 181 +/- 8 cm, weight = 85 +/- 14 kg, BMI = 26 +/- 3 kg/m2, peak normoxic VO2 = 36 +/- 6 ml/kg, mean +/- SD). Subjects were randomized to placebo or 100 mg sildenafil 1 h prior to entering a hypoxic tent with an FiO2 of 12.5% for 90 min. DLCO, VC, and DM were assessed at rest, every 3 min during exercise, at peak exercise, and 10 and 30 min post exercise. Sildenafil attenuated the elevation in PAP at rest and during recovery with exposure to hypoxia, but pulmonary arterial pressure immediately post exercise was not different between sildenafil and placebo. Systemic 02 saturation and VO2peak did not differ between the two conditions. DLCO was not different between groups at any time point. VC was higher with exercise in the placebo group, and the difference in DM between sildenafil and placebo was significant only when corrected for changes in VC (DM/VC = 0.57 +/- 0.29 vs. 0.41 +/- 0.16, P = 0.04). These results suggest no effect of sildenafil on DLCO, but an improvement in DM when corrected for changes in VC during short-term hypoxic exposure with exercise. |
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Authors:
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Eric M Snyder; Thomas P Olson; Bruce D Johnson; Robert P Frantz |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of applied physiology Volume: 103 ISSN: 1439-6319 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-08-21 Completed Date: 2008-09-18 Revised Date: 2011-04-15 |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 421-30 Citation Subset: IM |
Affiliation:
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Department of Pharmacy Practice and Science, University of Arizona, 1703 E. Mabel, Tucson, AZ 85721, USA. snyder@pharmacy.arizona.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Anoxia / drug therapy*, physiopathology* Capillaries / drug effects, physiology Cross-Over Studies Cyclic GMP / blood Double-Blind Method Endothelin-1 / blood Exercise / physiology Female Heart Rate / drug effects, physiology Humans Male Natriuretic Peptide, Brain / blood Oxygen / blood Piperazines / administration & dosage* Pulmonary Alveoli / blood supply, physiology Pulmonary Circulation / drug effects*, physiology* Pulmonary Gas Exchange / drug effects, physiology Purines / administration & dosage Rest / physiology Stroke Volume / drug effects, physiology Sulfones / administration & dosage* Vasodilator Agents / administration & dosage* |
| Grant Support | |
ID/Acronym/Agency:
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DK007013-31/DK/NIDDK NIH HHS; HL71478/HL/NHLBI NIH HHS; M01-RR00585/RR/NCRR NIH HHS; R01 HL071478-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 114471-18-0/Natriuretic Peptide, Brain; 139755-83-2/sildenafil; 7665-99-8/Cyclic GMP; 7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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