Document Detail

Influence of sibutramine on energy expenditure in African American women.
MedLine Citation:
PMID:  11331428     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: African American women have a high prevalence of obesity, which partially may be explained by their lower rates of resting energy expenditure (REE). The aim of this study was to examine the influence of acute sibutramine administration on REE and post-exercise energy expenditure in African American women. RESEARCH METHODS AND PROCEDURES: A total of 15 premenopausal, African American women (age, 29 +/- 5 years; body fat, 38 +/- 7%) completed a randomized, double-blind cross-over design with a 30-mg ingestion of sibutramine or a placebo. Each trial was completed a month apart in the follicular phase and included a 30-minute measurement of REE 2.5 hours after sibutramine or placebo administration. This was followed by 40 minutes of cycling at approximately 70% of peak aerobic capacity and a subsequent 2-hour measurement of post-cycling energy expenditure. RESULTS: There was no difference (p > 0.05) in REE (23.70 +/- 2.81 vs. 23.69 +/- 2.95 kcal/30 min), exercise oxygen consumption (1.22 +/- 0.15 vs. 1.25 +/- 0.15 liter/min), and post-cycling energy expenditure (104.2 +/- 12.7 vs. 104.9 +/- 11.4 kcal/120 min) between the sibutramine and placebo trials, respectively. Cycling heart rate was significantly higher (p = 0.01) during the sibutramine (158 +/- 14 beats/min) vs. placebo (150 +/- 12 beats/min) trials. DISCUSSION: These data demonstrate that acute sibutramine ingestion does not increase REE or post-exercise energy expenditures but does increase exercising heart rate in overweight African American women. Sibutramine may, therefore, impact weight loss through energy intake and not energy expenditure mechanisms.
R D Starling; X Liu; D H Sullivan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Obesity research     Volume:  9     ISSN:  1071-7323     ISO Abbreviation:  Obes. Res.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-05-01     Completed Date:  2001-06-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9305691     Medline TA:  Obes Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-6     Citation Subset:  IM    
Department of Geriatricsm University of Arkansas for Medical Sciences, Little Rock 72205, USA.
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MeSH Terms
African Continental Ancestry Group* / genetics
Appetite Depressants / pharmacology*
Basal Metabolism / drug effects
Cross-Over Studies
Cyclobutanes / pharmacology*
Double-Blind Method
Energy Metabolism / drug effects*,  genetics
Exercise / physiology
Heart Rate / drug effects
Obesity / drug therapy*,  genetics
Oxygen Consumption / drug effects
Grant Support
Reg. No./Substance:
0/Appetite Depressants; 0/Cyclobutanes; 106650-56-0/sibutramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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