| Influence of short-term water deprivation on kinetics of trimethadione and its metabolite in rats. | |
| | |
MedLine Citation:
|
PMID: 3795625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of acute (24-, 48- or 72-hr) water deprivation on the disposition kinetics of trimethadione (TMO) and its only metabolite, dimethadione (DMO), and on the microsomal hepatic drug-oxidizing enzyme activities were investigated in male rats. The DMO/TMO ratios in the serum at 2 hr after intravenous administration of 100 mg/kg TMO were significantly decreased in 48- and 72-hr water-deprived rats, but in 24-hr water-deprived rats, the DMO/TMO ratios were not changed as compared to controls and food restrictions. In the 48- and 72-hr water-deprived rats, contents of cytochrome p-450 and activities of aminopyrine N-demethylase were significantly decreased. On the other hand, activities of aniline hydroxylase in these rats were significantly increased as compared to controls and food restrictions. These results suggest that the effects of water deprivation on drug metabolism not only depend on the time of water deprivation but also vary with the indicator substrate. |
| | |
Authors:
|
E Tanaka; N Kurata; Y Kuroiwa; S Misawa |
Related Documents
:
|
9018075 - Metabolism of carcinogenic n-nitroso-n-methylaniline by purified cytochromes p450 2b1 a... 6815045 - Immunofluorescence of phenobarbital inducible cytochrome p-450 in the hepatic lobule of... 6500065 - Mechanism of foetal wastage following immunoneutralization of riboflavin carrier protei... 2263625 - A different cytochrome p450 form is induced in primary cultures of rat hepatocytes. 8064375 - Prediction of liver vitamin a in rats by an oral isotope dilution technique. 8467525 - Myosin-i in mammalian liver. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Japanese journal of pharmacology Volume: 42 ISSN: 0021-5198 ISO Abbreviation: Jpn. J. Pharmacol. Publication Date: 1986 Oct |
Date Detail:
|
Created Date: 1987-02-19 Completed Date: 1987-02-19 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 2983305R Medline TA: Jpn J Pharmacol Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 269-74 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aminopyrine N-Demethylase
/
metabolism Aniline Hydroxylase / metabolism Animals Cytochrome P-450 Enzyme System / metabolism Dimethadione / blood* Food Deprivation / physiology Kinetics Male Microsomes, Liver / enzymology* Oxazoles / blood* Rats Rats, Inbred Strains Trimethadione / blood* Water Deprivation / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Oxazoles; 127-48-0/Trimethadione; 695-53-4/Dimethadione; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.14.-/Aniline Hydroxylase; EC 1.5.3.-/Aminopyrine N-Demethylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lipid deposition in the aorta of adjuvant arthritic rats with hypercholesterolemia.
Next Document: Studies on responsiveness of hepatoma cells to catecholamines. IV. Lack of adrenergic activation of ...