Document Detail


Influence of short-term lithium carbonate administration on stimulated insulin secretion in normal man.
MedLine Citation:
PMID:  3108170     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have studied the effects of short-term treatment with lithium carbonate (900-1,200 mg/day for 4 days) on insulin secretion and blood glucose levels of 28 healthy volunteers (8 females and 20 males, aged 23-29 years) who underwent the following stimulations: two intravenous glucose loads of 25 and 5 g (IVGTT25; IVGTT5); arginine infusion (25 g over 30 min); tolbutamide test (0.25 g i.v.). Seven subjects for each group were tested. A placebo treatment was also performed. Short-term lithium treatment significantly reduced the insulin response to IVGTT25, arginine and tolbutamide. No differences were observed in blood glucose levels during all stimuli. Serum electrolyte levels and thyroid function were not affected by the treatment. In conclusion, these findings suggest, in healthy subjects, a good peripheral glucose utilization after brief-term lithium administration, in spite of impaired insulin response to various stimuli.
Authors:
F Caviezel; A G Cattaneo; G Cetta; G Pozza
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  25     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-08     Completed Date:  1987-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  188-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Arginine / diagnostic use
Blood Glucose / metabolism
Electrolytes / blood
Female
Glucose / diagnostic use
Humans
Insulin / secretion*
Lithium / administration & dosage,  blood,  pharmacology*
Lithium Carbonate
Male
Thyroid Function Tests
Time Factors
Tolbutamide / diagnostic use
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Electrolytes; 11061-68-0/Insulin; 50-99-7/Glucose; 554-13-2/Lithium Carbonate; 64-77-7/Tolbutamide; 74-79-3/Arginine; 7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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