Document Detail

Influence of sex hormone disturbances on the internal structure of the mandible in newborn mice.
MedLine Citation:
PMID:  16415085     Owner:  NLM     Status:  MEDLINE    
It has not yet been clarified how sex hormones affect craniofacial bone development immediately after birth. The purpose of this study was to examine the effects of sex hormone deficiency on craniofacial bone development immediately after birth, in terms of the internal structure of the mandible in newborn mice with orchiectomy (ORX) and ovariectomy (OVX). ORX, OVX and a sham-operation were performed on 40 five-day-old C57BL/6J mice. Eight weeks after surgery, each mandible was subjected to histomorphometric analysis of trabecular (Tr) and cortical (Ct) bone mineral density (BMD) by peripheral quantitative computed tomography (pQCT). In the experimental groups, a significant reduction in BMD was found in comparison with the control groups. In histomorphometric analysis, the number of tartrate-resistant acid phosphatase (TRAP)-positive cells in the condyle and the thickness of the condylar cartilage layer was significantly greater in the experimental mice than in the controls. Trabecular bone volume of the condyle measured on azocarmine-aniline blue (AZAN) sections was significantly less in the experimental mice than in the controls. These results indicate that mandibular growth is inhibited by sex hormone disturbances and the relevant internal structures changed. The findings show that sex hormones are one of the key determinants of mandibular growth and development immediately after birth.
T Fujita; J Ohtani; M Shigekawa; T Kawata; M Kaku; S Kohno; M Motokawa; Y Tohma; K Tanne
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-13
Journal Detail:
Title:  European journal of orthodontics     Volume:  28     ISSN:  0141-5387     ISO Abbreviation:  Eur J Orthod     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-29     Completed Date:  2006-05-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909010     Medline TA:  Eur J Orthod     Country:  England    
Other Details:
Languages:  eng     Pagination:  190-4     Citation Subset:  D; IM    
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, Japan.
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MeSH Terms
Acid Phosphatase / analysis
Animals, Newborn
Biological Markers / analysis
Bone Density / physiology
Cartilage, Articular / pathology
Chondrogenesis / physiology
Estrogens / deficiency*
Facial Bones / growth & development
Isoenzymes / analysis
Mandible / growth & development,  pathology*
Mandibular Condyle / pathology
Mice, Inbred C57BL
Mice, Inbred Strains
Osteoclasts / pathology
Osteogenesis / physiology
Skull / growth & development
Testosterone / deficiency*
Tomography, X-Ray Computed
Reg. No./Substance:
0/Biological Markers; 0/Estrogens; 0/Isoenzymes; 58-22-0/Testosterone; EC 3.1.3.-/tartrate-resistant acid phosphatase; EC Phosphatase

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