Document Detail

Influence of the selective prostaglandin biosynthesis inhibitor, gold, on the arterial pressure of normotensive and spontaneously hypertensive rats.
MedLine Citation:
PMID:  742308     Owner:  NLM     Status:  MEDLINE    
Gold salt treatment does not influence the blood pressure of normotensive rats but transiently lowers the blood pressure of spontaneously hypertensive rats. The effect is abolished by indomethacin. Prostaglandin (PG) synthesis in the kidney medulla is shifted to E-PG by gold salt. A PG-mediated action of gold salts is supposed.
P Hoffmann; H U Block; W Förster
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta biologica et medica Germanica     Volume:  37     ISSN:  0001-5318     ISO Abbreviation:  Acta Biol. Med. Ger.     Publication Date:  1978  
Date Detail:
Created Date:  1979-04-25     Completed Date:  1979-04-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370276     Medline TA:  Acta Biol Med Ger     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  887-8     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Gold / pharmacology*
Hypertension / physiopathology*
Indomethacin / pharmacology
Kidney Medulla / drug effects,  metabolism
Prostaglandins / biosynthesis*
Prostaglandins E / biosynthesis
Prostaglandins F / biosynthesis
Thiosulfates / pharmacology
Reg. No./Substance:
0/Prostaglandins; 0/Prostaglandins E; 0/Prostaglandins F; 0/Thiosulfates; 53-86-1/Indomethacin; 7440-57-5/Gold

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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