Document Detail

Influence of the selection of angiographic projections on the results of coronary angiographic follow-up trials. International Nifedipine Trial on Antiatherosclerotic Therapy Investigators.
MedLine Citation:
PMID:  7661057     Owner:  NLM     Status:  MEDLINE    
In recent years follow-up trials on coronary artery disease with angiographic end points analyzed quantitatively have gained increasing relevance and popularity. There is no consensus, however, on the method of calculation of progression or regression from multiple angiographic projections. Therefore the influence of the selection of angiographic projections on the outcomes of such trials was investigated with the data of the International Nifedipine Trial on Antiatherosclerotic Therapy. In 348 patients with coronary artery disease, repeated coronary angiograms were compared in multiple identical angiographic projections. Changes in angiographic parameters were averaged over the 1063 stenoses analyzed. Five methods of evaluation of multiple projections in the individual stenoses were applied, resulting in different extents of overall progression, or even regression of coronary artery disease (p < 0.01). It is concluded that in quantitative coronary angiographic follow-up trials changes should be averaged over all angiographic projections available for a stenosis to avoid overestimation of progression or regression.
S Jost; J Deckers; P Nikutta; J H Reiber; W Rafflenbeul; B Wiese; H Hecker; P Lichtlen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  130     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-10-04     Completed Date:  1995-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  433-9     Citation Subset:  AIM; IM    
Department of Cardiology, Hannover Medical School, Germany.
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MeSH Terms
Analysis of Variance
Coronary Angiography / methods*,  statistics & numerical data
Coronary Disease / drug therapy*,  radiography*
Disease Progression
Double-Blind Method
Follow-Up Studies
International Cooperation
Nifedipine / therapeutic use*
Prospective Studies
Remission Induction
Reg. No./Substance:

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