| Influence of the selection of angiographic projections on the results of coronary angiographic follow-up trials. International Nifedipine Trial on Antiatherosclerotic Therapy Investigators. | |
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MedLine Citation:
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PMID: 7661057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In recent years follow-up trials on coronary artery disease with angiographic end points analyzed quantitatively have gained increasing relevance and popularity. There is no consensus, however, on the method of calculation of progression or regression from multiple angiographic projections. Therefore the influence of the selection of angiographic projections on the outcomes of such trials was investigated with the data of the International Nifedipine Trial on Antiatherosclerotic Therapy. In 348 patients with coronary artery disease, repeated coronary angiograms were compared in multiple identical angiographic projections. Changes in angiographic parameters were averaged over the 1063 stenoses analyzed. Five methods of evaluation of multiple projections in the individual stenoses were applied, resulting in different extents of overall progression, or even regression of coronary artery disease (p < 0.01). It is concluded that in quantitative coronary angiographic follow-up trials changes should be averaged over all angiographic projections available for a stenosis to avoid overestimation of progression or regression. |
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Authors:
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S Jost; J Deckers; P Nikutta; J H Reiber; W Rafflenbeul; B Wiese; H Hecker; P Lichtlen |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American heart journal Volume: 130 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1995 Sep |
Date Detail:
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Created Date: 1995-10-04 Completed Date: 1995-10-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 433-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Hannover Medical School, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Coronary Angiography / methods*, statistics & numerical data Coronary Disease / drug therapy*, radiography* Disease Progression Double-Blind Method Follow-Up Studies Humans International Cooperation Nifedipine / therapeutic use* Prospective Studies Recurrence Remission Induction |
| Chemical | |
Reg. No./Substance:
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21829-25-4/Nifedipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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