Document Detail

Influence of selected amino acid deficiencies on somatomedin, growth and glycosaminoglycan metabolism in weanling rats.
MedLine Citation:
PMID:  3923165     Owner:  NLM     Status:  MEDLINE    
The effects of lysine-, methionine- or histidine-deficient diets compared to a control diet fed ad libitum or 15, 10 or 5 g/d were studied in weanling rats. Feed intake was 5-7 g/d for the amino acid-deficient animals. After 3 wk, all amino acid-deficient rats had lost more weight (P less than 0.01) than the controls fed at comparable energy levels. Serum somatomedin (Sm) activity was significantly decreased in lysine- (0.55 U/ml), methionine- (0.32 U/ml) and histidine-deficient (0.38 U/ml) rats compared to rats fed the control diet ad libitum (1.6 U/ml). Differences between amino acid-deficient and calorie-restricted animals were not significant. A similar response was observed in 35SO4 uptake by cartilage glycosaminoglycans (GAG). Caloric restriction and amino acid deficiency each resulted in lower 35SO4 uptake by cartilage GAG than occurred with ad libitum feeding, but there were no significant differences between the rats fed amino acid-deficient diets and those fed 5 or 10 g of the control diet. Compared to rats fed the control diet ad libitum, plasma growth hormone (GH) concentrations were lower in the rats fed 5 or 10 g of control diet per day and in those fed amino acid-deficient diets (P less than 0.05), but GH concentrations were not consistent with the growth retardation observed. The results confirm that Sm and GAG activities are reduced in protein-energy restriction independent of GH. However, changes could not be attributed to specific deficiencies of lysine, methionine and/or histidine.
M S Bolze; R D Reeves; F E Lindbeck; M J Elders
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  115     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-07-24     Completed Date:  1985-07-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  782-7     Citation Subset:  IM    
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MeSH Terms
Amino Acids, Essential / deficiency*
Body Weight
Energy Intake
Glycosaminoglycans / metabolism*
Growth Hormone / blood
Histidine / deficiency
Lysine / deficiency
Methionine / deficiency
Rats, Inbred Strains
Somatomedins / blood*
Sulfates / metabolism
Grant Support
Reg. No./Substance:
0/Amino Acids, Essential; 0/Glycosaminoglycans; 0/Somatomedins; 0/Sulfates; 56-87-1/Lysine; 63-68-3/Methionine; 71-00-1/Histidine; 9002-72-6/Growth Hormone

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