| Influence of seizures on lipids of homogenate and neuronal and glial nuclei of rat neocortex. | |
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MedLine Citation:
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PMID: 15527415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipid composition of homogenate and neuronal and glial nuclei of the brain cortex of Wistar rats was studied under normal conditions and after seizures induced by injection of picrotoxin. Seizures increased contents of lysophosphatidylcholine, sphingomyelin, and total phospholipids in the homogenate. In neuronal nuclei contents of total phospholipids, sphingomyelin, phosphatidylcholine, and phosphatidylserine decreased, and contents of free fatty acids and lysophosphatidylcholine increased. In glial nuclei content of total phospholipids decreased and content of free fatty acids increased. The role of changes in the lipid composition of the neocortex cells during seizures and the involvement of lipid messengers in signal mechanisms are discussed. |
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Authors:
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T P Kulagina; N A Shevchenko; V I Arkhipov |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemistry. Biokhimii͡a Volume: 69 ISSN: 0006-2979 ISO Abbreviation: Biochemistry Mosc. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-11-05 Completed Date: 2005-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376536 Medline TA: Biochemistry (Mosc) Country: United States |
Other Details:
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Languages: eng Pagination: 1143-7 Citation Subset: IM |
Affiliation:
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Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia. kulagina@icb.psn.ru |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Nucleus / metabolism, ultrastructure Convulsants DNA / metabolism Lipid Metabolism* Lysophosphatidylcholines / metabolism Male Microscopy, Electron Neocortex / metabolism* Neuroglia / metabolism* Neurons / metabolism* Nuclear Proteins / metabolism Picrotoxin Rats Seizures / chemically induced, metabolism* Sphingomyelins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Convulsants; 0/Lysophosphatidylcholines; 0/Nuclear Proteins; 0/Sphingomyelins; 124-87-8/Picrotoxin; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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