Document Detail

Influence of the salt moiety on the effectiveness of corticosteroid therapy in cardiogenic shock.
MedLine Citation:
PMID:  7046986     Owner:  NLM     Status:  MEDLINE    
Using closed chest coronary artery microsphere embolization, myocardial infarction and subsequent shock were produced in healthy adult mongrel dogs. Following infarction animals were distributed among the following groups: (1) control; (2) methylprednisolone sodium succinate (MPSS); (3) methylprednisolone sodium phosphate (MPSP); (4) sodium phosphate (SP); and (5) sodium succinate (SS). Drug doses of equivalent anti-inflammatory activity were administered i.v. 15 min after infarction. Compared to control animals, only dogs treated with MPSS exhibited significant improvements in hemodynamic parameters and permanent survival. Survival in MPSS dogs was significantly (P = 0.02) better than that of either group treated with SP or SS and substantially (P = 0.02) better than that of either group treated with SP or SS and substantially (P = 0.065) better than the survival rate of dogs receiving MPSP. It appears that succinate is permissive, while phosphate is restrictive, with respect to efficacy of methylprednisolone in experimental cardiogenic shock. Possible explanations for these observations are discussed.
C H Shatney; R C Lillehei; R H Dietzman; L H Romero; C B Beckman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulatory shock     Volume:  9     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1982  
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  247-58     Citation Subset:  IM    
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use*
Drug Synergism
Methylprednisolone / analogs & derivatives,  pharmacology
Methylprednisolone Hemisuccinate / pharmacology
Phosphates / pharmacology
Shock, Cardiogenic / drug therapy*
Sodium / pharmacology*
Succinates / pharmacology
Succinic Acid
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Phosphates; 0/Succinates; 110-15-6/Succinic Acid; 2921-57-5/Methylprednisolone Hemisuccinate; 5015-36-1/methylprednisolone sodium phosphate; 7440-23-5/Sodium; 7632-05-5/sodium phosphate; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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