| Influence of residual normal metaphases in acute myeloid leukemiapatients with monosomal karyotype. | |
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MedLine Citation:
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PMID: 21330329 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Monosomal karyotype (MK), defined as 2 autosomal monosomies or 1 autosomal monosomy plus a structural abnormality, conveys a worse prognosis in untreated AML than a complex karyotype. Previous data suggested that the presence of residual normal cells improved prognosis in monosomy 7 AML, prompting us to see if the same was true in patients with MK. Among 176 MK patients identified in Southwest Oncology Group trials, survival improved as the percentage of normal cells increased. Having one or more normal cells was associated with a hazard ratio (HR) of 0.95 (p=0.02), while 5 normal cells decreased the HR to 0.76. Accounting for age and treatment did not alter these results. However, the survival of even MK patients with normal metaphases remains very poor. Nonetheless our results suggest that the potential utility of examining the effect of residual normal cells in patients with better prognosis karyotypes. |
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Authors:
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Bin Xie; Megan Othus; Bruno C Medeiros; Min Fang; Frederick R Appelbaum; Elihu H Estey |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-17 |
Journal Detail:
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Title: Haematologica Volume: - ISSN: 1592-8721 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417435 Medline TA: Haematologica Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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USA; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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